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    CYP4F8 cytochrome P450 family 4 subfamily F member 8 [ Homo sapiens (human) ]

    Gene ID: 11283, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CYP4F8provided by HGNC
    Official Full Name
    cytochrome P450 family 4 subfamily F member 8provided by HGNC
    Primary source
    HGNC:HGNC:2648
    See related
    Ensembl:ENSG00000186526 MIM:611545; AllianceGenome:HGNC:2648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPF8; CYPIVF8
    Summary
    This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 2.3), skin (RPKM 0.2) and 2 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CYP4F8 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15615218..15630639)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15740324..15755884)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15726029..15741449)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904644 Neighboring gene ribosomal protein L23a pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10286 Neighboring gene cytochrome P450 family 4 subfamily F member 3 Neighboring gene cytochrome P450 family 4 subfamily F member 10, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. Bylund J, et al. J Biol Chem, 2000 Jul 21. PMID 10791960
    2. Oxidation of prostaglandin H(2) and prostaglandin H(2) analogues by human cytochromes P450: analysis of omega-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I(1) by mass spectrometry. Oliw EH, et al. Biochem Pharmacol, 2001 Aug 15. PMID 11448449
    3. Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. Stark K, et al. Arch Biochem Biophys, 2003 Jan 1. PMID 12464258
    4. New Proluciferin Substrates for Human CYP4 Family Enzymes. Liu J, et al. Appl Biochem Biotechnol, 2021 Jan. PMID 32869209
    5. Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. Bylund J, et al. Biochem Biophys Res Commun, 1999 Jul 22. PMID 10405341

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New Proluciferin Substrates for Human CYP4 Family Enzymes.
      Title: New Proluciferin Substrates for Human CYP4 Family Enzymes.
    2. The PLA2G7, HPGD, EPHX2, and CYP4F8 genes are highly expressed in prostate cancer.
      Title: Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
    4. PGH synthase-2, CYP4F8, and PGE synthase-1 likely forms 19-hydroxy-PGE compounds in seminal vesicles and vas deferens
      Title: On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens.
    5. We conclude that CYP4F8 and CYP4F12 catalyze epoxidation of 22:6n-3 and 22:5n-3, and CYP4F8 omega3-hydroxylation of 22:5n-6.
      Title: Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.
    6. expression analysis of CYP4F8 shows that high levels are found in epithelial linings and epidermis of psoriatic lesions
      Title: Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in icosanoid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in menaquinone catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phylloquinone catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4F8
    Names
    cytochrome P450, family 4, subfamily F, polypeptide 8
    cytochrome P450, subfamily IVF, polypeptide 8
    flavoprotein-linked monooxygenase
    microsomal monooxygenase
    NP_009184.1
    XP_024307109.1
    XP_054175663.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008068.1 RefSeqGene

      Range
      5001..20422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007253.4 → NP_009184.1  cytochrome P450 4F8

      See identical proteins and their annotated locations for NP_009184.1

      Status: REVIEWED

      Source sequence(s)
      AD000685, AF133298, AI401776, DA871128, DA877298, DB329701
      Consensus CDS
      CCDS74303.1
      UniProtKB/Swiss-Prot
      P98187
      UniProtKB/TrEMBL
      B2RBJ0
      Related
      ENSP00000477567.1, ENST00000612078.5
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 504
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15615218..15630639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451341.2 → XP_024307109.1  cytochrome P450 4F8 isoform X1

      UniProtKB/TrEMBL
      B2RBJ0
      Related
      ENST00000441682.6
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 417
      p450; Cytochrome P450

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      15740324..15755884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319688.1 → XP_054175663.1  cytochrome P450 4F8 isoform X1

      UniProtKB/TrEMBL
      B2RBJ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98187.1 GenPept UniProtKB/Swiss-Prot:P98187

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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