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    TNS1 tensin 1 [ Gallus gallus (chicken) ]

    Gene ID: 396439, updated on 3-Dec-2024

    Summary

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    Symbol
    TNS1provided by CGNC
    Full Name
    tensin 1provided by CGNC
    Primary source
    CGNC:66228
    See related
    Ensembl:ENSGALG00010019050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TNS
    Orthologs
    human mouse all
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    Genomic context

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    See TNS1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (22218576..22272601)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (22138226..22192253)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene angio associated migratory cell protein Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene C-X-C motif chemokine receptor 1 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene uncharacterized LOC101749755 Neighboring gene uncharacterized LOC101749715

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of tensin and vimentin expression in chick embryo developing cartilage and cultured differentiating chondrocytes. van de Werken R, et al. Eur J Biochem, 1993 Oct 15. PMID 8223621
    2. Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization. Lo SH, et al. J Biol Chem, 1994 Sep 2. PMID 8071358
    3. Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin. Chuang JZ, et al. J Cell Biol, 1995 Mar. PMID 7896874, Free PMC Article
    4. Presence of an SH2 domain in the actin-binding protein tensin. Davis S, et al. Science, 1991 May 3. PMID 1708917
    5. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Qian X, et al. Proc Natl Acad Sci U S A, 2007 May 22. PMID 17517630, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tensin-1; tensin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396437.1 → NP_001383366.1  tensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011
      Conserved Domains (5) summary
      cd09927
      Location:1468 → 1583
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:986 → 1415
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:648 → 954
      PRK10263; DNA translocase FtsK; Provisional
      cd01213
      Location:1605 → 1738
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14560
      Location:68 → 226
      PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

    2. NM_001396438.1 → NP_001383367.1  tensin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      Conserved Domains (5) summary
      smart00109
      Location:21 → 67
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd09927
      Location:945 → 1060
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:472 → 889
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1082 → 1215
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14560
      Location:121 → 279
      PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

    3. NM_001396440.1 → NP_001383369.1  tensin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V0ZA33
      Related
      ENSGALP00010027501.1, ENSGALT00010046138.1
      Conserved Domains (5) summary
      cd09927
      Location:1456 → 1571
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:825 → 1382
      PHA03247; large tegument protein UL36; Provisional
      PRK07003
      Location:670 → 955
      PRK07003; DNA polymerase III subunit gamma/tau
      cd01213
      Location:1593 → 1726
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14560
      Location:68 → 226
      PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      22218576..22272601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943529.1 → XP_046799485.1  tensin isoform X9

      UniProtKB/TrEMBL
      A0A8V0Z969

    2. XM_046943524.1 → XP_046799480.1  tensin isoform X4

      UniProtKB/TrEMBL
      A0A8V0Z969
      Related
      ENSGALP00010027502.1, ENSGALT00010046143.1

    3. XM_046943527.1 → XP_046799483.1  tensin isoform X7

      UniProtKB/TrEMBL
      A0A8V0Z969
      Related
      ENSGALP00010027503.1, ENSGALT00010046145.1

    4. XM_046943534.1 → XP_046799490.1  tensin isoform X14

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    5. XM_046943535.1 → XP_046799491.1  tensin isoform X15

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    6. XM_046943531.1 → XP_046799487.1  tensin isoform X11

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    7. XM_046943533.1 → XP_046799489.1  tensin isoform X13

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    8. XM_046943521.1 → XP_046799477.1  tensin isoform X1

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    9. XM_046943522.1 → XP_046799478.1  tensin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZA33

    10. XM_046943525.1 → XP_046799481.1  tensin isoform X5

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    11. XM_046943528.1 → XP_046799484.1  tensin isoform X8

      UniProtKB/TrEMBL
      A0A8V0ZA33

    12. XM_046943526.1 → XP_046799482.1  tensin isoform X6

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    13. XM_046943530.1 → XP_046799486.1  tensin isoform X10

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    14. XM_046943532.1 → XP_046799488.1  tensin isoform X12

      UniProtKB/TrEMBL
      A0A8V0ZA33
      Related
      ENSGALP00010027500.1, ENSGALT00010046135.1

    15. XM_046943538.1 → XP_046799494.1  tensin isoform X17

    16. XM_046943523.1 → XP_046799479.1  tensin isoform X3

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    17. XM_046943537.1 → XP_046799493.1  tensin isoform X16

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    18. XM_046943536.1 → XP_046799492.1  tensin isoform X16

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      22138226..22192253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921198.1 → XP_046777154.1  tensin isoform X9

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011
      UniProtKB/TrEMBL
      A0A8V0Z969

    2. XM_046921192.1 → XP_046777148.1  tensin isoform X4

      UniProtKB/TrEMBL
      A0A8V0Z969

    3. XM_046921196.1 → XP_046777152.1  tensin isoform X7

      UniProtKB/TrEMBL
      A0A8V0Z969

    4. XM_046921203.1 → XP_046777159.1  tensin isoform X14

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    5. XM_046921204.1 → XP_046777160.1  tensin isoform X15

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    6. XM_046921200.1 → XP_046777156.1  tensin isoform X11

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    7. XM_046921202.1 → XP_046777158.1  tensin isoform X13

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    8. XM_046921189.1 → XP_046777145.1  tensin isoform X1

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    9. XM_046921190.1 → XP_046777146.1  tensin isoform X2

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    10. XM_046921193.1 → XP_046777149.1  tensin isoform X5

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    11. XM_046921197.1 → XP_046777153.1  tensin isoform X8

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    12. XM_046921194.1 → XP_046777150.1  tensin isoform X6

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    13. XM_046921199.1 → XP_046777155.1  tensin isoform X10

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    14. XM_046921201.1 → XP_046777157.1  tensin isoform X12

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    15. XM_046921208.1 → XP_046777164.1  tensin isoform X17

    16. XM_046921191.1 → XP_046777147.1  tensin isoform X3

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    17. XM_046921207.1 → XP_046777163.1  tensin isoform X16

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    18. XM_046921205.1 → XP_046777161.1  tensin isoform X16

      UniProtKB/Swiss-Prot
      A0A1L1RRE9, Q04205, Q91007, Q92011

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_205455.1: Suppressed sequence

      Description
      NM_205455.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04205.3 GenPept UniProtKB/Swiss-Prot:Q04205

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials