MSLN mesothelin [Homo sapiens (human)] - Gene

Summary

Official Symbol: MSLNprovided by HGNC
Official Full Name: mesothelinprovided by HGNC
Primary source: HGNC:HGNC:7371
See related: Ensembl:ENSG00000102854 MIM:601051; AllianceGenome:HGNC:7371
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MPF; SMRP
Summary: This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Expression: Biased expression in lung (RPKM 16.4), stomach (RPKM 4.7) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (760734..768865)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (764710..773383)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (810734..818865)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer.
Title: Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer.
Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.
Title: Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.
Enhanced Expression of Glycolytic Enzymes and Succinate Dehydrogenase Complex Flavoprotein Subunit A by Mesothelin Promotes Glycolysis and Mitochondrial Respiration in Myeloblasts of Acute Myeloid Leukemia.
Title: Enhanced Expression of Glycolytic Enzymes and Succinate Dehydrogenase Complex Flavoprotein Subunit A by Mesothelin Promotes Glycolysis and Mitochondrial Respiration in Myeloblasts of Acute Myeloid Leukemia.
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope.
Title: Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope.
Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.
Title: Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.
High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma.
Title: High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma.
Effects of hsa-mir-145-5p on the Regulation of msln Expression in Colorectal Adenocarcinoma.
Title: Effects of hsa-mir-145-5p on the Regulation of msln Expression in Colorectal Adenocarcinoma.
Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.
Title: Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.
Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway.
Title: Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway.
Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment.
Title: Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment.

Submit: New GeneRIF Correction See all GeneRIFs (150)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mesothelin

Names: CAK1 antigen; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177355.3 → NP_001170826.1 mesothelin isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001170826.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AL031258, AY743922, BC003512, BC009272

Consensus CDS

CCDS45370.1

UniProtKB/Swiss-Prot

Q13421

Related

ENSP00000456008.1, ENST00000563941.5

Conserved Domains (1) summary

pfam06060
Location:1 → 608

Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
NM_005823.6 → NP_005814.2 mesothelin isoform 1 preproprotein

See identical proteins and their annotated locations for NP_005814.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Both variants 1 and 3 encode the same isoform isoform (1).

Source sequence(s)

AL031258, AY743922, BC003512

Consensus CDS

CCDS45370.1

UniProtKB/Swiss-Prot

Q13421

Related

ENSP00000442965.2, ENST00000545450.7

Conserved Domains (1) summary

pfam06060
Location:1 → 608

Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
NM_013404.4 → NP_037536.2 mesothelin isoform 2 preproprotein

See identical proteins and their annotated locations for NP_037536.2

Status: REVIEWED

Description

Transcript Variant: This transcript variant (2) uses an alternate splice site in the coding region, compared to variant 1. Variant 2 encodes isoform 2 which is longer than isoform 1.

Source sequence(s)

AL545401, BC003512, BC009272, CB266931, D49441

Consensus CDS

CCDS32356.1

UniProtKB/Swiss-Prot

D3DU65, Q13421, Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UCB2, Q9UK57

Related

ENSP00000372313.3, ENST00000382862.7

Conserved Domains (1) summary

pfam06060
Location:1 → 616

Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)