Sntn sentan, cilia apical structure protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sntnprovided by MGI
Official Full Name: sentan, cilia apical structure proteinprovided by MGI
Primary source: MGI:MGI:3045373
See related: Ensembl:ENSMUSG00000044772 AllianceGenome:MGI:3045373
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A430083B19Rik
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Located in cilium. Is expressed in lung epithelium and nasal cavity respiratory epithelium. Orthologous to human SNTN (sentan, cilia apical structure protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in lung adult (RPKM 2.7), ovary adult (RPKM 1.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 6.93 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (8786615..8798887, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (13670876..13683148)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport.
Title: Sentan: a novel specific component of the apical structure of vertebrate motile cilia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sentan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177624.3 → NP_808292.1 sentan

See identical proteins and their annotated locations for NP_808292.1

Status: PROVISIONAL

Source sequence(s)

AK040281

Consensus CDS

CCDS26822.1

UniProtKB/Swiss-Prot

B7FF66, Q8C9X1

Related

ENSMUSP00000062092.3, ENSMUST00000061045.3

Conserved Domains (2) summary

cd00213
Location:54 → 137

S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...

pfam13499
Location:74 → 127

EF-hand_7; EF-hand domain pair