Ntn4 netrin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntn4provided by MGI
Official Full Name: netrin 4provided by MGI
Primary source: MGI:MGI:1888978
See related: Ensembl:ENSMUSG00000020019 AllianceGenome:MGI:1888978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables laminin-1 binding activity. Acts upstream of or within neuron remodeling and regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling. Located in basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; connective tissue; genitourinary system; and nervous system. Orthologous to human NTN4 (netrin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 32.3), kidney adult (RPKM 17.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 48.59 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (93476911..93581834)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (93641049..93745972)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression.
Title: The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression.
Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.
Title: Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.
netrin-4 disrupts laminin networks and basement membranes through high-affinity binding to the laminin gamma-1 chain.
Title: Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.
we found that Ntn4 promotes differentiation and migration of osteoblasts.
Title: Netrin-4 Promotes Differentiation and Migration of Osteoblasts.
Netrin-4 acted as an antiangiogenic factor in the cornea, with which the healthy cornea is enriched via its expression by corneal epithelial cells.
Title: Netrin-4 Mediates Corneal Hemangiogenesis but Not Lymphangiogenesis in the Mouse-Model of Suture-Induced Neovascularization.
Our results indicate a role for netrin-4 as an angiogenesis modulating factor in O2-dependent vascular homeostasis while being less important during normal retinal developmental angiogenesis or during inflammatory neovascularization.
Title: Lack of netrin-4 modulates pathologic neovascularization in the eye.
These results indicate that netrin-4 shed new light on its potential roles in treatmenting for angiogenic diseases that affect the ocular surface, as well as other tissues
Title: Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats.
Vascular endothelial cells interact with bone in suppressing bone through netrin-4.
Title: Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo.
Loss of Netrin-4 is associated with metastatic colorectal tumor progression.
Title: Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression.
The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells.
Title: Netrin-4 activates endothelial integrin {alpha}6{beta}1.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables laminin-1 binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: netrin-4

Names: beta-netrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021320.3 → NP_067295.2 netrin-4 precursor

See identical proteins and their annotated locations for NP_067295.2

Status: VALIDATED

Source sequence(s)

AC151976, BB609851, BC119182, CF537120, CJ068258, CX205916

Consensus CDS

CCDS24128.1

UniProtKB/Swiss-Prot

E9QMT3, Q9JI33

UniProtKB/TrEMBL

Q0VEM1

Related

ENSMUSP00000020204.5, ENSMUST00000020204.5

Conserved Domains (4) summary

cd00055
Location:261 → 320

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03578
Location:517 → 626

NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...

pfam00053
Location:395 → 449

Laminin_EGF; Laminin EGF domain

pfam00055
Location:43 → 260

Laminin_N; Laminin N-terminal (Domain VI)