Clec10a C-type lectin domain family 10, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec10aprovided by MGI
Official Full Name: C-type lectin domain family 10, member Aprovided by MGI
Primary source: MGI:MGI:96975
See related: Ensembl:ENSMUSG00000000318 AllianceGenome:MGI:96975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mgl; Mgl1; CD301a; M-ASGP-BP-1
Summary: Predicted to enable D-mannose binding activity; fucose binding activity; and pattern recognition receptor activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human CLEC10A (C-type lectin domain containing 10A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 20.4), bladder adult (RPKM 15.0) and 9 other tissues See more
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70057449..70061662)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70166623..70170836)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report.
Title: Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report.
Intestinal lamina propria macrophages upregulate interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a.
Title: Intestinal lamina propria macrophages upregulate interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a.
CD301 mediates fusion in IL-4-driven multinucleated giant cell formation.
Title: CD301 mediates fusion in IL-4-driven multinucleated giant cell formation.
MGL1 Receptor Plays a Key Role in the Control of T. cruzi Infection by Increasing Macrophage Activation through Modulation of ERK1/2, c-Jun, NF-kappaB and NLRP3 Pathways.
Title: MGL1 Receptor Plays a Key Role in the Control of T. cruzi Infection by Increasing Macrophage Activation through Modulation of ERK1/2, c-Jun, NF-κB and NLRP3 Pathways.
Our findings suggest that Clec10a in mice and Asgr1 in humans play an important role in skin homeostasis against inflammation associated with house dust mite-induced dermatitis.
Title: Clec10a regulates mite-induced dermatitis.
Loss of Mgl1 expression is associated with enhanced alpha2-3Neu-von Willebrand factor clearance.
Title: A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance.
Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia
Title: Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia.
Mgl1-deficient mice displayed accelerated colonic propulsion and were hypersensitive to mu receptor-mediated inhibition of colonic motility.
Title: Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity.
MGL1 is involved in T. crassiceps recognition and subsequent innate immune activation and resistance.
Title: The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection.
The MGL1 functions as an attachment and entry receptor for influenza A virus.
Title: The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Spontaneous (1) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236623

Clec10a (e-PCR), detects polymorphism
- UniSTS:536451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables fucose binding	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type lectin domain family 10 member A

Names: macrophage asialoglycoprotein-binding protein 1; macrophage galactose N-acetyl-galactosamine specific lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204252.1 → NP_001191181.1 C-type lectin domain family 10 member A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL669869

Consensus CDS

CCDS56784.1

UniProtKB/TrEMBL

F8WHB7, Q3TCD3

Related

ENSMUSP00000000327.7, ENSMUST00000000327.13

Conserved Domains (2) summary

cd03590
Location:174 → 299

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:14 → 164

Lectin_N; Hepatic lectin, N-terminal domain
NM_010796.3 → NP_034926.1 C-type lectin domain family 10 member A isoform 2

See identical proteins and their annotated locations for NP_034926.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AL669869

Consensus CDS

CCDS24936.1

UniProtKB/Swiss-Prot

P49300, Q549F6, Q91YT3

UniProtKB/TrEMBL

Q3TCD3

Related

ENSMUSP00000099631.4, ENSMUST00000102571.10

Conserved Domains (2) summary

cd03590
Location:173 → 298

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:16 → 163

Lectin_N; Hepatic lectin, N-terminal domain