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    Zfp474 zinc finger protein 474 [ Mus musculus (house mouse) ]

    Gene ID: 66758, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp474provided by MGI
    Official Full Name
    zinc finger protein 474provided by MGI
    Primary source
    MGI:MGI:1914008
    See related
    Ensembl:ENSMUSG00000046886 AllianceGenome:MGI:1914008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf474; 4933409D10Rik
    Summary
    Predicted to enable metal ion binding activity. Is expressed in axial skeleton; lung; lung epithelium; and nasal cavity respiratory epithelium. Orthologous to human ZNF474 (zinc finger protein 474). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 35.4) See more
    Orthologs
    human all
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    Genomic context

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    See Zfp474 in Genome Data Viewer
    Location:
    18 D1; 18 28.24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52748979..52772904)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52615906..52639832)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44604 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 41724 Neighboring gene RIKEN cDNA 1700034E13 gene Neighboring gene glycerol kinase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    2. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 474
    Names
    TSZFP
    testis-specific zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360984.1 → NP_001347913.1  zinc finger protein 474

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC161119
      Consensus CDS
      CCDS29248.1
      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Related
      ENSMUSP00000147873.2, ENSMUST00000209270.2
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    2. NM_025749.3 → NP_080025.3  zinc finger protein 474

      See identical proteins and their annotated locations for NP_080025.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK016749
      Consensus CDS
      CCDS29248.1
      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Related
      ENSMUSP00000072453.4, ENSMUST00000072666.4
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      52748979..52772904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526159.4 → XP_006526222.1  zinc finger protein 474 isoform X1

      See identical proteins and their annotated locations for XP_006526222.1

      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    2. XM_006526160.4 → XP_006526223.1  zinc finger protein 474 isoform X1

      See identical proteins and their annotated locations for XP_006526223.1

      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    3. XM_011246984.4 → XP_011245286.1  zinc finger protein 474 isoform X1

      See identical proteins and their annotated locations for XP_011245286.1

      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    4. XM_011246983.4 → XP_011245285.1  zinc finger protein 474 isoform X1

      See identical proteins and their annotated locations for XP_011245285.1

      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    5. XM_036161245.1 → XP_036017138.1  zinc finger protein 474 isoform X1

      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    6. XM_036161247.1 → XP_036017140.1  zinc finger protein 474 isoform X1

      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type

    7. XM_036161246.1 → XP_036017139.1  zinc finger protein 474 isoform X1

      UniProtKB/Swiss-Prot
      Q6V5K9, Q9D472, Q9D985
      Conserved Domains (1) summary
      pfam13913
      Location:281 → 304
      zf-C2HC_2; zinc-finger of a C2HC-type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6V5K9.2 GenPept UniProtKB/Swiss-Prot:Q6V5K9

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