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    Tmem120a transmembrane protein 120A [ Mus musculus (house mouse) ]

    Gene ID: 215210, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem120aprovided by MGI
    Official Full Name
    transmembrane protein 120Aprovided by MGI
    Primary source
    MGI:MGI:2686991
    See related
    Ensembl:ENSMUSG00000039886 AllianceGenome:MGI:2686991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmpit; 2010310D06Rik
    Summary
    Enables monoatomic ion channel activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of pain; fat cell differentiation; and protein complex oligomerization. Located in plasma membrane. Is expressed in central nervous system and ganglia. Orthologous to human TMEM120A (transmembrane protein 120A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 93.9), subcutaneous fat pad adult (RPKM 83.5) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmem120a in Genome Data Viewer
    Location:
    5 G2; 5 75.38 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135764344..135773026, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135735490..135744172, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome p450 oxidoreductase Neighboring gene STARR-positive B cell enhancer ABC_E435 Neighboring gene predicted gene, 40345 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14588 Neighboring gene microRNA 7034 Neighboring gene STARR-positive B cell enhancer ABC_E9654 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136254330-136254517 Neighboring gene predicted gene, 30205 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coenzyme A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ion channel TACAN
    Names
    transmembrane protein induced by tumor necrosis factor alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172541.2NP_766129.1  ion channel TACAN

      See identical proteins and their annotated locations for NP_766129.1

      Status: PROVISIONAL

      Source sequence(s)
      AK028119
      Consensus CDS
      CCDS19744.1
      UniProtKB/Swiss-Prot
      Q8BWP7, Q8C1E7
      Related
      ENSMUSP00000045252.3, ENSMUST00000043378.9
      Conserved Domains (1) summary
      pfam07851
      Location:13336
      TMPIT; TMPIT-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135764344..135773026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)