Krt75 keratin 75 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt75provided by MGI
Official Full Name: keratin 75provided by MGI
Primary source: MGI:MGI:1923500
See related: Ensembl:ENSMUSG00000022986 AllianceGenome:MGI:1923500
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K6hf; Krtcap1; Krt2-6hf; 4732468K03Rik
Summary: Predicted to be a structural constituent of skin epidermis. Acts upstream of or within hematopoietic progenitor cell differentiation. Is active in cornified envelope. Is expressed in incisor; larynx; skin; urethra; and ventral grey horn. Orthologous to human KRT75 (keratin 75). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 15 F2; 15 56.91 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101471778..101482339, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101563343..101573904, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that keratin 75 (K75), a cytosolic protein lacking a signal sequence, is secreted into the forming enamel matrix utilizing portions of the conventional endoplasmic reticulum (ER)-Golgi secretory pathway.
Title: Trafficking and secretion of keratin 75 by ameloblasts in vivo.
mK6a and mK75 thus exhibit temporally distinct, and spatially opposed, expression patterns in the companion layer (Cl) during postnatal anagen.
Title: Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles.
Mice expressing mutant form of Krt75 developed hair and nail defects resembling pachyonychia congenita
Title: Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 75

Names: CK-75; K75; cytokeratin KRT2-6HF; cytokeratin-75; keratin 75 activity-regulated; keratin-6 hair follicle; keratinocyte associated protein 1; mK6hf; type II keratin-K6hf; type-II keratin Kb18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.