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    Utf1 undifferentiated embryonic cell transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 22286, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Utf1provided by MGI
    Official Full Name
    undifferentiated embryonic cell transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1276125
    See related
    Ensembl:ENSMUSG00000047751 AllianceGenome:MGI:1276125
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables HMG box domain binding activity; TBP-class protein binding activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; gonad; and limb mesenchyme. Orthologous to human UTF1 (undifferentiated embryonic cell transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 7.2), thymus adult (RPKM 4.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Utf1 in Genome Data Viewer
    Location:
    7 F4; 7 84.91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139523769..139525025)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139943856..139945112)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene kinase non-catalytic C-lobe domain (KIND) containing 1 Neighboring gene STARR-seq mESC enhancer starr_20433 Neighboring gene STARR-seq mESC enhancer starr_20437 Neighboring gene predicted gene 16201 Neighboring gene microRNA 7686 Neighboring gene microRNA 202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer. Raina K, et al. Stem Cell Rev Rep, 2021 Aug. PMID 33517544
    2. Carboxy-terminally truncated form of a coactivator UTF1 stimulates transcription from a variety of gene promoters through the TATA Box. Fukushima A, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329418
    3. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Nishimoto M, et al. Mol Cell Biol, 1999 Aug. PMID 10409735, Free PMC Article
    4. Utf1 contributes to intergenerational epigenetic inheritance of pluripotency. Bao Q, et al. Sci Rep, 2017 Nov 6. PMID 29097685, Free PMC Article
    5. UTF1 is a chromatin-associated protein involved in ES cell differentiation. van den Boom V, et al. J Cell Biol, 2007 Sep 10. PMID 17785516, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.
      Title: An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.
    2. proper development of Utf1 null embryos almost entirely depends on the presence of functional Utf1 alleles in the parental germline. This indicates that Utf1's proposed epigenetic role in ESC pluripotency in vitro may be linked to intergenerational epigenetic inheritance in vivo.
      Title: Utf1 contributes to intergenerational epigenetic inheritance of pluripotency.
    3. UTF1 is required for embryonic development and regulates male germ cell development
      Title: Embryonic lethality and defective male germ cell development in mice lacking UTF1.
    4. LncRNA Gm2044 was identified to inhibit Utf1 mRNA translation and play important roles in spermatogenesis.
      Title: LncRNA Gm2044 highly expresses in spermatocyte and inhibits Utf1 translation by interacting with Utf1 mRNA.
    5. IPS cells derived from UTF1-selection give rise to functional CMs in vitro.
      Title: Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1 -neo selection.
    6. A large region of Utf1 was found to be necessary for direct interaction with N-Myc.
      Title: Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain.
    7. Suppression of UTF1 expression in P19 cells by RNA interference enhanced retinoic acid (RA)-induced neuronal differentiation.
      Title: UTF1 deficiency promotes retinoic acid-induced neuronal differentiation in P19 embryonal carcinoma cells.
    8. Data show that UTF1 is a key chromatin component in ES cells, preventing ES cell chromatin decondensation, and aberrant gene expression; both essential for proper initiation of lineage-specific differentiation of ES cells.
      Title: Undifferentiated embryonic cell transcription factor 1 regulates ESC chromatin organization and gene expression.
    9. UTF1 is a strongly chromatin-associated protein involved in the initiation of ES cell differentiation.
      Title: UTF1 is a chromatin-associated protein involved in ES cell differentiation.
    10. These results suggest a molecular pathway by which Oct-3/4 induces rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene.
      Title: Oct-3/4 maintains the proliferative embryonic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables HMG box domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    undifferentiated embryonic cell transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009482.2 → NP_033508.1  undifferentiated embryonic cell transcription factor 1

      See identical proteins and their annotated locations for NP_033508.1

      Status: PROVISIONAL

      Source sequence(s)
      AC107822
      Consensus CDS
      CCDS21958.1
      UniProtKB/Swiss-Prot
      O70530, Q6J1H4
      UniProtKB/TrEMBL
      B2RSF1
      Related
      ENSMUSP00000128848.3, ENSMUST00000168457.3
      Conserved Domains (1) summary
      pfam13837
      Location:79 → 126
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139523769..139525025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6J1H4.2 GenPept UniProtKB/Swiss-Prot:Q6J1H4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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