Ifne interferon epsilon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifneprovided by MGI
Official Full Name: interferon epsilonprovided by MGI
Primary source: MGI:MGI:2667156
See related: Ensembl:ENSMUSG00000045364 AllianceGenome:MGI:2667156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: If1ea; Ifne1; Ifnt1; Infe1; Ifn-tau-1
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Involved in defense response to bacterium and defense response to virus. Predicted to be active in extracellular space. Is expressed in diencephalon floor plate and midbrain floor plate. Orthologous to human IFNE (interferon epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 4 C4; 4 42.04 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (88797775..88798438, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (88879538..88880201, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Interferon Epsilon in Mucosal Epithelium is Regulated by Elf3.
Title: Expression of Interferon Epsilon in Mucosal Epithelium is Regulated by Elf3.
Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection.
Title: Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection.
IFN-epsilon is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines.
Title: IFN-ε is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines.
IFN-epsilon could promote migration of antigen-specific CD8(+)T cells to the gut.
Title: Role of novel type I interferon epsilon in viral infection and mucosal immunity.
Ifn-epsilon-deficient mice had increased susceptibility to infection of the female reproductive tract by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum.
Title: Interferon-ε protects the female reproductive tract from viral and bacterial infection.
interactions between estradiol and IFN-tau in the context of the overall immune response during autoimmune orchitis
Title: 17β-Estradiol and interferon tau interact in the regulation of the immune response in a model of experimental autoimmune orchitis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info
enables type I interferon receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon epsilon

Names: IFN-epsilon; interferon 1ea; interferon epsilon 1; interferon tau-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.