Gpr139 G protein-coupled receptor 139 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr139provided by MGI
Official Full Name: G protein-coupled receptor 139provided by MGI
Primary source: MGI:MGI:2685341
See related: Ensembl:ENSMUSG00000066197 AllianceGenome:MGI:2685341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGR3; GPRg1; Gm495
Summary: Enables identical protein binding activity and neuropeptide receptor activity. Involved in G protein-coupled receptor signaling pathway. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including ileum; liver; male reproductive gland or organ; nervous system; and spleen. Orthologous to human GPR139 (G protein-coupled receptor 139). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 4.1), CNS E18 (RPKM 3.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 63.79 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (118739970..118783761, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (119140747..119184538, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin.
Title: The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin.
The role of orphan receptor GPR139 in neuropsychiatric behavior.
Title: The role of orphan receptor GPR139 in neuropsychiatric behavior.
Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models.
Title: Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models.
The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.
Title: The orphan receptor GPR139 signals via G(q/11) to oppose opioid effects.
GPR139 modulates behavioral responses to opioids. Deletion of GPR139 in mice enhanced opioid-induced inhibition of neuronal firing to modulate morphine-induced analgesia, reward, and withdrawal.
Title: Genetic behavioral screen identifies an orphan anti-opioid system.
GPR139 mRNA was predominantly expressed in specific areas of mouse brain during pre- and postnatal development.
Title: Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492105

D1Mco33 (e-PCR)
- UniSTS:240512

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: probable G-protein coupled receptor 139

Names: G protein-coupled receptor PGR3; g(q)-coupled orphan receptor GPRg1; orphan G protein-coupled receptor TRHRL2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.