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    Rexo5 RNA exonuclease 5 [ Mus musculus (house mouse) ]

    Gene ID: 434234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rexo5provided by MGI
    Official Full Name
    RNA exonuclease 5provided by MGI
    Primary source
    MGI:MGI:1919402
    See related
    Ensembl:ENSMUSG00000030924 AllianceGenome:MGI:1919402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610020H08Rik
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human REXO5 (RNA exonuclease 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 4.4), CNS E11.5 (RPKM 2.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rexo5 in Genome Data Viewer
    Location:
    7 F2; 7 64.21 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119393331..119488130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119794117..119880443)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57786 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene exoribonuclease 2 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_20041 Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 53369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' → 5' exoribonuclease. Silva S, et al. RNA, 2017 Sep. PMID 28539487, Free PMC Article
    2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59529

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease 5
    Names
    exonuclease NEF-sp

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004187.1 → NP_001004187.1  RNA exonuclease 5 isoform 1

      See identical proteins and their annotated locations for NP_001004187.1

      Status: VALIDATED

      Source sequence(s)
      BC053445
      Consensus CDS
      CCDS21787.1
      UniProtKB/TrEMBL
      Q7TSF9
      Related
      ENSMUSP00000033218.9, ENSMUST00000033218.15
      Conserved Domains (2) summary
      cl10012
      Location:225 → 317
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:424 → 462
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001370778.1 → NP_001357707.1  RNA exonuclease 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122423, AC164158
      UniProtKB/TrEMBL
      D3YW29
      Related
      ENSMUSP00000102130.2, ENSMUST00000106520.9
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_028129.2 → NP_082405.1  RNA exonuclease 5 isoform 2

      See identical proteins and their annotated locations for NP_082405.1

      Status: VALIDATED

      Source sequence(s)
      AC122423, AC164158
      Consensus CDS
      CCDS21788.1
      UniProtKB/TrEMBL
      D3Z3J7
      Related
      ENSMUSP00000081694.3, ENSMUST00000084644.3
      Conserved Domains (2) summary
      cd06145
      Location:33 → 181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298 → 368
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119393331..119488130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241845.4 → XP_011240147.1  RNA exonuclease 5 isoform X1

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006507994.5 → XP_006508057.1  RNA exonuclease 5 isoform X5

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_036153220.1 → XP_036009113.1  RNA exonuclease 5 isoform X4

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:555 → 625
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_006507991.5 → XP_006508054.1  RNA exonuclease 5 isoform X2

      See identical proteins and their annotated locations for XP_006508054.1

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_030242744.2 → XP_030098604.1  RNA exonuclease 5 isoform X2

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_006507990.5 → XP_006508053.1  RNA exonuclease 5 isoform X2

      See identical proteins and their annotated locations for XP_006508053.1

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_030242746.2 → XP_030098606.1  RNA exonuclease 5 isoform X6

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. XM_006507992.5 → XP_006508055.1  RNA exonuclease 5 isoform X3

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_006508000.5 → XP_006508063.1  RNA exonuclease 5 isoform X15

      See identical proteins and their annotated locations for XP_006508063.1

      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 528
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_006507998.5 → XP_006508061.1  RNA exonuclease 5 isoform X12

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 560
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. XM_036153228.1 → XP_036009121.1  RNA exonuclease 5 isoform X13

      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:555 → 598
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. XM_006507999.5 → XP_006508062.1  RNA exonuclease 5 isoform X15

      See identical proteins and their annotated locations for XP_006508062.1

      Conserved Domains (2) summary
      cd06145
      Location:225 → 373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490 → 528
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. XM_036153221.1 → XP_036009114.1  RNA exonuclease 5 isoform X7

      UniProtKB/TrEMBL
      A0A1Z1GHX5
      Conserved Domains (2) summary
      cl10012
      Location:225 → 317
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:424 → 494
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. XM_036153227.1 → XP_036009120.1  RNA exonuclease 5 isoform X11

      Conserved Domains (2) summary
      cd06145
      Location:33 → 181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298 → 368
      RRM_SF; RNA recognition motif (RRM) superfamily

    15. XM_036153229.1 → XP_036009122.1  RNA exonuclease 5 isoform X14

      Conserved Domains (2) summary
      cd06145
      Location:145 → 293
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:410 → 480
      RRM_SF; RNA recognition motif (RRM) superfamily

    16. XM_036153226.1 → XP_036009119.1  RNA exonuclease 5 isoform X11

      Conserved Domains (2) summary
      cd06145
      Location:33 → 181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298 → 368
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. XM_036153224.1 → XP_036009117.1  RNA exonuclease 5 isoform X10

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:126 → 274
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:391 → 461
      RRM_SF; RNA recognition motif (RRM) superfamily

    18. XM_036153223.1 → XP_036009116.1  RNA exonuclease 5 isoform X9

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:143 → 291
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:408 → 478
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. XM_036153225.1 → XP_036009118.1  RNA exonuclease 5 isoform X11

      Conserved Domains (2) summary
      cd06145
      Location:33 → 181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298 → 368
      RRM_SF; RNA recognition motif (RRM) superfamily

    20. XM_036153222.1 → XP_036009115.1  RNA exonuclease 5 isoform X8

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:145 → 293
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:410 → 480
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_869733.4 RNA Sequence

    2. XR_378253.5 RNA Sequence

    3. XR_378258.5 RNA Sequence

      Related
      ENSMUST00000133758.9

    4. XR_004934130.1 RNA Sequence

    5. XR_004934132.1 RNA Sequence

    6. XR_004934131.1 RNA Sequence

    7. XR_004934133.1 RNA Sequence

    8. XR_004934134.1 RNA Sequence

    9. XR_004934135.1 RNA Sequence

    10. XR_004934136.1 RNA Sequence

    11. XR_004934137.1 RNA Sequence

    12. XR_004934138.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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