Pih1d2 PIH1 domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pih1d2provided by MGI
Official Full Name: PIH1 domain containing 2provided by MGI
Primary source: MGI:MGI:1919864
See related: Ensembl:ENSMUSG00000000167 AllianceGenome:MGI:1919864
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700059L22Rik
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in box C/D snoRNP assembly and rRNA processing. Predicted to be part of R2TP complex; protein folding chaperone complex; and ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in 4th ventricle; 4th ventricle lateral recess; choroid plexus; lateral ventricle choroid plexus; and olfactory epithelium. Orthologous to human PIH1D2 (PIH1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 8.7), CNS E11.5 (RPKM 0.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (50528621..50536300)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (50617321..50625000)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in box C/D snoRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of R2TP complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of protein folding chaperone complex	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PIH1 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028300.2 → NP_082576.1 PIH1 domain-containing protein 2

See identical proteins and their annotated locations for NP_082576.1

Status: VALIDATED

Source sequence(s)

AC025500, AK012458, AV281140, AW488473

Consensus CDS

CCDS23167.1

UniProtKB/Swiss-Prot

Q05CZ6, Q8CHR9, Q9CSM2

Related

ENSMUSP00000000171.9, ENSMUST00000000171.15

Conserved Domains (1) summary

cl00175
Location:25 → 313

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

50528621..50536300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510627.4 → XP_006510690.1 PIH1 domain-containing protein 2 isoform X1

Conserved Domains (2) summary

pfam18201
Location:244 → 329

PIH1_CS; PIH1 CS-like domain

cl00175
Location:41 → 184

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.