Crtc1 CREB regulated transcription coactivator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crtc1provided by MGI
Official Full Name: CREB regulated transcription coactivator 1provided by MGI
Primary source: MGI:MGI:2142523
See related: Ensembl:ENSMUSG00000003575 AllianceGenome:MGI:2142523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mect1; TORC1; TORC-1; mKIAA0616
Summary: Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Involved in entrainment of circadian clock by photoperiod and positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including memory; negative regulation of membrane hyperpolarization; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Used to study major depressive disorder. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 24.8), cortex adult (RPKM 22.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.15 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70835002..70892720, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70382352..70439702, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis.
Title: Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis.
Downregulation of mTORC1 and Mcl-1 by lipid-oversupply contributes to islet beta-cell apoptosis and dysfunction.
Title: Downregulation of mTORC1 and Mcl-1 by lipid-oversupply contributes to islet β-cell apoptosis and dysfunction.
Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior.
Title: Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior.
CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance.
Title: CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance.
Downregulation of CRTC1 Is Involved in CUMS-Induced Depression-Like Behavior in the Hippocampus and Its RNA Sequencing Analysis.
Title: Downregulation of CRTC1 Is Involved in CUMS-Induced Depression-Like Behavior in the Hippocampus and Its RNA Sequencing Analysis.
Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity.
Title: Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity.
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Title: Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
MTORC1 inhibition drives crinophagic degradation of glucagon.
Title: MTORC1 inhibition drives crinophagic degradation of glucagon.
Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
Title: Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD.
Title: Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI413414 (e-PCR)
- UniSTS:159771

NoName (e-PCR)
- UniSTS:235913

AI071469 (e-PCR)
- UniSTS:261026

RH125134 (e-PCR)
- UniSTS:161956

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of membrane hyperpolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CREB-regulated transcription coactivator 1

Names: mucoepidermoid carcinoma translocated 1; mucoepidermoid carcinoma translocated protein 1 homolog; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004062.3 → NP_001004062.1 CREB-regulated transcription coactivator 1 isoform 2

See identical proteins and their annotated locations for NP_001004062.1

Status: VALIDATED

Source sequence(s)

AC158553

Consensus CDS

CCDS40372.1

UniProtKB/Swiss-Prot

Q68ED7, Q6ZQ85

Related

ENSMUSP00000075916.6, ENSMUST00000076615.6

Conserved Domains (3) summary

pfam12884
Location:6 → 66

TORC_N; Transducer of regulated CREB activity, N terminus

pfam12885
Location:148 → 289

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:555 → 630

TORC_C; Transducer of regulated CREB activity, C terminus
NM_001404415.1 → NP_001391344.1 CREB-regulated transcription coactivator 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404416.1 → NP_001391345.1 CREB-regulated transcription coactivator 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404417.1 → NP_001391346.1 CREB-regulated transcription coactivator 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404418.1 → NP_001391347.1 CREB-regulated transcription coactivator 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404419.1 → NP_001391348.1 CREB-regulated transcription coactivator 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404420.1 → NP_001391349.1 CREB-regulated transcription coactivator 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404421.1 → NP_001391350.1 CREB-regulated transcription coactivator 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404422.1 → NP_001391351.1 CREB-regulated transcription coactivator 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404423.1 → NP_001391352.1 CREB-regulated transcription coactivator 1 isoform 10

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404424.1 → NP_001391353.1 CREB-regulated transcription coactivator 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404425.1 → NP_001391354.1 CREB-regulated transcription coactivator 1 isoform 12

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404426.1 → NP_001391355.1 CREB-regulated transcription coactivator 1 isoform 13

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404427.1 → NP_001391356.1 CREB-regulated transcription coactivator 1 isoform 14

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404428.1 → NP_001391357.1 CREB-regulated transcription coactivator 1 isoform 15

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404429.1 → NP_001391358.1 CREB-regulated transcription coactivator 1 isoform 16

Status: VALIDATED

Source sequence(s)

AC158553
NM_001404430.1 → NP_001391359.1 CREB-regulated transcription coactivator 1 isoform 16

Status: VALIDATED

Source sequence(s)

AC158553

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

70835002..70892720 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242309.4 → XP_011240611.1 CREB-regulated transcription coactivator 1 isoform X2

Conserved Domains (3) summary

pfam12884
Location:6 → 66

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:148 → 316

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:553 → 628

TORC_C; Transducer of regulated CREB activity, C-terminus
XM_011242312.3 → XP_011240614.1 CREB-regulated transcription coactivator 1 isoform X6

Conserved Domains (2) summary

pfam12885
Location:23 → 161

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:427 → 502

TORC_C; Transducer of regulated CREB activity, C-terminus
XM_036154147.1 → XP_036010040.1 CREB-regulated transcription coactivator 1 isoform X6

Conserved Domains (2) summary

pfam12885
Location:23 → 161

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:427 → 502

TORC_C; Transducer of regulated CREB activity, C-terminus
XM_011242313.4 → XP_011240615.1 CREB-regulated transcription coactivator 1 isoform X7

Conserved Domains (2) summary

pfam12885
Location:1 → 157

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:423 → 498

TORC_C; Transducer of regulated CREB activity, C-terminus
XM_011242314.4 → XP_011240616.1 CREB-regulated transcription coactivator 1 isoform X12

Conserved Domains (2) summary

pfam12884
Location:6 → 66

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:148 → 316

TORC_M; Transducer of regulated CREB activity middle domain