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    Qrfpr pyroglutamylated RFamide peptide receptor [ Mus musculus (house mouse) ]

    Gene ID: 229214, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Qrfprprovided by MGI
    Official Full Name
    pyroglutamylated RFamide peptide receptorprovided by MGI
    Primary source
    MGI:MGI:2677633
    See related
    Ensembl:ENSMUSG00000058400 AllianceGenome:MGI:2677633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AQ27; Gpr103; SP9155; Gpr103a
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Located in non-motile cilium. Is expressed in ventral pallium. Used to study bone structure disease. Orthologous to human QRFPR (pyroglutamylated RFamide peptide receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 1.2), frontal lobe adult (RPKM 0.8) and 8 other tissues See more
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    Genomic context

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    See Qrfpr in Genome Data Viewer
    Location:
    3 B; 3 17.41 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36233575..36276462, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36179426..36222275, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54173 Neighboring gene STARR-positive B cell enhancer ABC_E10177 Neighboring gene zinc finger protein 267 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 11 Neighboring gene STARR-seq mESC enhancer starr_07420 Neighboring gene STARR-seq mESC enhancer starr_07421 Neighboring gene STARR-seq mESC enhancer starr_07422 Neighboring gene predicted gene, 42208 Neighboring gene predicted gene, 42209 Neighboring gene hemopexin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Anxiolytic effect of the GPR103 receptor agonist peptide P550 (homolog of neuropeptide 26RFa) in mice. Involvement of neurotransmitters. Palotai M, et al. Peptides, 2016 Aug. PMID 27224020
    2. The G-protein-coupled receptor GPR103 regulates bone formation. Baribault H, et al. Mol Cell Biol, 2006 Jan. PMID 16382160, Free PMC Article
    3. Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development. Patel SK, et al. Int J Biol Macromol, 2019 Feb 1. PMID 30219516
    4. The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors. Cook C, et al. PLoS One, 2022. PMID 36251705, Free PMC Article
    5. GPR103b functions in the peripheral regulation of adipogenesis. Mulumba M, et al. Mol Endocrinol, 2010 Aug. PMID 20534693, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
      Title: The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
    2. Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development
      Title: Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development.
    3. we treated mice with the synthetic GPR103 receptor agonist peptide P550 and the anxious behavior was investigated using an elevated plus-maze test.
      Title: Anxiolytic effect of the GPR103 receptor agonist peptide P550 (homolog of neuropeptide 26RFa) in mice. Involvement of neurotransmitters.
    4. Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
      Title: GPR103b functions in the peripheral regulation of adipogenesis.
    5. Osteopenia in GPR103-/- mice may be mediated directly by the loss of GPR103 expression in bone.
      Title: The G-protein-coupled receptor GPR103 regulates bone formation.
    6. QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
      Title: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
    7. characterization and tissue distribution of SP9155 (GPR103) ligand [GPR103/SP9155]
      Title: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyroglutamylated RF-amide peptide receptor
    Names
    G protein-coupled receptor 103
    QRFP receptor
    orexigenic neuropeptide QRFP receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198192.3 → NP_937835.1  pyroglutamylated RF-amide peptide receptor

      See identical proteins and their annotated locations for NP_937835.1

      Status: VALIDATED

      Source sequence(s)
      AC102844
      Consensus CDS
      CCDS17311.1
      UniProtKB/Swiss-Prot
      P83861
      UniProtKB/TrEMBL
      Q3UQ27, Q4VA00
      Related
      ENSMUSP00000088768.6, ENSMUST00000091227.9
      Conserved Domains (1) summary
      cd15205
      Location:46 → 343
      7tmA_QRFPR; pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      36233575..36276462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83861.1 GenPept UniProtKB/Swiss-Prot:P83861

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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