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    Pnpla5 patatin-like phospholipase domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 75772, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pnpla5provided by MGI
    Official Full Name
    patatin-like phospholipase domain containing 5provided by MGI
    Primary source
    MGI:MGI:1923022
    See related
    Ensembl:ENSMUSG00000018868 AllianceGenome:MGI:1923022
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GS2L; 4833426H19Rik
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA5 (patatin like phospholipase domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Pnpla5 in Genome Data Viewer
    Location:
    15 E2; 15 39.78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83996631..84007567, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84112621..84123175, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 6 Neighboring gene ribosomal protein L31, pseudogene 22 Neighboring gene sulfotransferase family 4A, member 1 Neighboring gene predicted gene, 46526 Neighboring gene predicted gene, 33432 Neighboring gene STARR-seq mESC enhancer starr_39351 Neighboring gene predicted gene, 33530

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130406, MGC130407

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    patatin-like phospholipase domain-containing protein 5
    NP_083703.1
    XP_036015516.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029427.1 → NP_083703.1  patatin-like phospholipase domain-containing protein 5

      See identical proteins and their annotated locations for NP_083703.1

      Status: PROVISIONAL

      Source sequence(s)
      BC109360
      Consensus CDS
      CCDS49685.1
      UniProtKB/Swiss-Prot
      Q32LZ8, Q9D603
      Related
      ENSMUSP00000019012.4, ENSMUST00000019012.4
      Conserved Domains (1) summary
      cd07223
      Location:1 → 403
      Pat_PNPLA5-mammals; Patatin-like phospholipase domain containing protein 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83996631..84007567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159623.1 → XP_036015516.1  patatin-like phospholipase domain-containing protein 5 isoform X1

      Related
      ENSMUSP00000155268.2, ENSMUST00000230566.2
      Conserved Domains (1) summary
      cd07223
      Location:1 → 403
      Pat_PNPLA5-mammals; Patatin-like phospholipase domain containing protein 5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32LZ8.1 GenPept UniProtKB/Swiss-Prot:Q32LZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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