Ypel4 yippee like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ypel4provided by MGI
Official Full Name: yippee like 4provided by MGI
Primary source: MGI:MGI:3605071
See related: Ensembl:ENSMUSG00000034059 AllianceGenome:MGI:3605071
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including negative regulation of erythrocyte clearance; negative regulation of erythrocyte differentiation; and protein localization to plasma membrane. Predicted to be located in nucleolus. Is expressed in forebrain. Orthologous to human YPEL4 (yippee like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14.5 (RPKM 48.4), liver E14 (RPKM 41.5) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84564355..84568999)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (84734011..84738655)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.
Title: Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of erythrocyte clearance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein yippee-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005342.2 → NP_001005342.1 protein yippee-like 4

See identical proteins and their annotated locations for NP_001005342.1

Status: PROVISIONAL

Source sequence(s)

AB098743

Consensus CDS

CCDS16192.1

UniProtKB/Swiss-Prot

Q65Z93

UniProtKB/TrEMBL

A0A571BG63, Q0VEE5

Related

ENSMUSP00000088231.3, ENSMUST00000090729.9

Conserved Domains (1) summary

cl13152
Location:28 → 118

RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

84564355..84568999

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499466.4 → XP_006499529.1 protein yippee-like 4 isoform X1

See identical proteins and their annotated locations for XP_006499529.1

UniProtKB/Swiss-Prot

Q65Z93

UniProtKB/TrEMBL

A0A571BG63, Q0VEE5

Related

ENSMUSP00000158708.2, ENSMUST00000238573.2

Conserved Domains (1) summary

cl13152
Location:28 → 118

RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
XM_036161892.1 → XP_036017785.1 protein yippee-like 4 isoform X1

UniProtKB/Swiss-Prot

Q65Z93

UniProtKB/TrEMBL

A0A571BG63, Q0VEE5

Conserved Domains (1) summary

cl13152
Location:28 → 118

RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains