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    Nudt11 nudix hydrolase 11 [ Mus musculus (house mouse) ]

    Gene ID: 58242, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nudt11provided by MGI
    Official Full Name
    nudix hydrolase 11provided by MGI
    Primary source
    MGI:MGI:1930957
    See related
    Ensembl:ENSMUSG00000073295 AllianceGenome:MGI:1930957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIPP3; DIPP3b; Dipp3a; Nudt10
    Summary
    Enables diphosphoinositol-polyphosphate diphosphatase activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; lung; metanephros; and tooth. Orthologous to several human genes including NUDT11 (nudix hydrolase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 18.5), whole brain E14.5 (RPKM 16.1) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Nudt11 in Genome Data Viewer
    Location:
    X A1.1; X 2.68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (5959488..5966805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6047471..6054751)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 51614 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46652 Neighboring gene predicted gene 14450 Neighboring gene predicted gene, 26618 Neighboring gene STARR-seq mESC enhancer starr_46653 Neighboring gene ribosomal protein L19, pseudogene 12 Neighboring gene EZH inhibitory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bis(5'-adenosyl)-hexaphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diphosphoinositol-polyphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 3-beta
    Names
    DIPP-3-alpha
    DIPP-3-beta
    DIPP3-alpha
    DIPP3-beta
    Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha
    Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
    Nucleoside diphosphate-linked moiety X motif 10
    Nudix motif 10
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta
    diadenosine hexaphosphate hydrolase (AMP-forming)
    nucleoside diphosphate-linked moiety X motif 11
    nudix (nucleoside diphosphate linked moiety X)-type motif 11
    nudix motif 11
    nudix-type motif 11
    NP_067406.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021431.2NP_067406.2  diphosphoinositol polyphosphate phosphohydrolase 3-beta

      See identical proteins and their annotated locations for NP_067406.2

      Status: VALIDATED

      Source sequence(s)
      BC071274, BX465866
      Consensus CDS
      CCDS29955.1
      UniProtKB/Swiss-Prot
      P0C027, P0C028, Q8BKF4, Q9JJD3
      Related
      ENSMUSP00000100072.4, ENSMUST00000103007.4
      Conserved Domains (1) summary
      cd04666
      Location:18137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      5959488..5966805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003953019.2 RNA Sequence