Krt6b keratin 6B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt6bprovided by MGI
Official Full Name: keratin 6Bprovided by MGI
Primary source: MGI:MGI:1333768
See related: Ensembl:ENSMUSG00000023041 AllianceGenome:MGI:1333768
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mK6[b]; Krt2-6b
Summary: Predicted to be a structural constituent of skin epidermis. Acts upstream of or within intermediate filament organization; keratinization; and morphogenesis of an epithelium. Predicted to be active in keratin filament. Is expressed in oral epithelium; skin; and tongue. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to human KRT6A (keratin 6A); KRT6B (keratin 6B); and KRT6C (keratin 6C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 16.8), CNS E18 (RPKM 1.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 56.97 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101584458..101588728, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101676023..101680293, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings reveal that K6a/K6b modulate keratinocyte migration by regulating cell-matrix and cell-cell adhesion and highlight a role for keratins in collective cell migration.
Title: Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.
Although K6a was not essential for mammary gland development, loss of both K6a and K6b resulted in an increase in PR-positive mammary epithelial cells and decreased proliferation after exposure to steroid hormones
Title: Keratin 6 is not essential for mammary gland development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Krt2-6b (e-PCR), detects polymorphism
- UniSTS:265264

NoName (e-PCR)
- UniSTS:488275

NoName (e-PCR)
- UniSTS:490836

PMC37340P1 (e-PCR)
- UniSTS:273303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within keratinization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 6B

Names: CK-6B; K6B; cytokeratin-6B; keratin complex 2, basic, gene 6b; keratin-6-beta; mK6-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010669.3 → NP_034799.2 keratin, type II cytoskeletal 6B

See identical proteins and their annotated locations for NP_034799.2

Status: VALIDATED

Source sequence(s)

AC120787

Consensus CDS

CCDS27859.1

UniProtKB/Swiss-Prot

Q9Z331

UniProtKB/TrEMBL

Q3UV11

Related

ENSMUSP00000023786.6, ENSMUST00000023786.7

Conserved Domains (3) summary

pfam00038
Location:151 → 464

Filament; Intermediate filament protein

pfam16208
Location:15 → 148

Keratin_2_head; Keratin type II head

cl01888
Location:377 → 437

DUF883; Bacterial protein of unknown function (DUF883)