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    St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 20451, updated on 27-Nov-2024

    Summary

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    Official Symbol
    St8sia3provided by MGI
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by MGI
    Primary source
    MGI:MGI:106019
    See related
    Ensembl:ENSMUSG00000056812 AllianceGenome:MGI:106019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat8c; ST8SiaIII
    Summary
    Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Involved in ganglioside biosynthetic process and sialylation. Predicted to be located in Golgi membrane. Is expressed in brain; cortical plate; and testis. Orthologous to human ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 10.9), CNS E18 (RPKM 10.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St8sia3 in Genome Data Viewer
    Location:
    18 E1; 18 37.25 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64387430..64409217)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64254359..64276146)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene peroxiredoxin 1, pseudogene 1 Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_44803 Neighboring gene one cut domain, family member 2 Neighboring gene STARR-seq mESC enhancer starr_44804 Neighboring gene STARR-seq mESC enhancer starr_44805

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D(2) and adenosine A(2A) receptors. Lin CY, et al. Transl Psychiatry, 2019 Aug 27. PMID 31455764, Free PMC Article
    2. Differential expression of disialic acids in the cerebellum of senile mice. Rinflerch AR, et al. Glycobiology, 2012 Mar. PMID 22038478
    3. Unique genomic structure and expression of the mouse alpha 2,8-sialyltransferase (ST8Sia III) gene. Yoshida Y, et al. Glycobiology, 1996 Sep. PMID 8922952
    4. Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8 sialyltransferase. Zeng G, et al. Gene, 1997 Mar 10. PMID 9073076
    5. Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3. Kono M, et al. J Biol Chem, 1996 Nov 15. PMID 8910600

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A significant decrease in ST8Sia III gene expression was found in the cerebellum of senile animals.
      Title: Differential expression of disialic acids in the cerebellum of senile mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-glycan processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ganglioside biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3; sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
    Names
    SIAT8-C
    alpha-2,8-sialyltransferase 8C
    alpha-2,8-sialyltransferase III
    ganglioside GD3 synthase ST8SIA3
    sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase
    sialyltransferase 8 (alpha-2, 8-sialyltransferase) C
    sialyltransferase 8C
    sialyltransferase St8Sia III
    sialytransferase St8Sia III
    NP_033208.2
    XP_030106227.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009182.3 → NP_033208.2  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

      See identical proteins and their annotated locations for NP_033208.2

      Status: VALIDATED

      Source sequence(s)
      AK015874, BB616760, BC075645
      Consensus CDS
      CCDS29301.1
      UniProtKB/Swiss-Prot
      Q64689, Q6DIB7
      UniProtKB/TrEMBL
      Q9CUJ6
      Related
      ENSMUSP00000025477.8, ENSMUST00000025477.15
      Conserved Domains (1) summary
      pfam00777
      Location:113 → 376
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      64387430..64409217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250367.2 → XP_030106227.1  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q64689, Q6DIB7
      UniProtKB/TrEMBL
      Q9CUJ6
      Related
      ENSMUSP00000158392.2, ENSMUST00000237770.2
      Conserved Domains (1) summary
      pfam00777
      Location:113 → 376
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64689.2 GenPept UniProtKB/Swiss-Prot:Q64689

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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