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    Hid1 HID1 domain containing [ Mus musculus (house mouse) ]

    Gene ID: 217310, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hid1provided by MGI
    Official Full Name
    HID1 domain containingprovided by MGI
    Primary source
    MGI:MGI:2445087
    See related
    Ensembl:ENSMUSG00000034586 AllianceGenome:MGI:2445087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C630004H02Rik
    Summary
    Predicted to be located in cytoplasmic microtubule; cytoplasmic side of Golgi membrane; and cytosol. Predicted to be active in Golgi medial cisterna; Golgi trans cisterna; and membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 105. Orthologous to human HID1 (HID1 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 50.9), stomach adult (RPKM 40.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hid1 in Genome Data Viewer
    Location:
    11 E2; 11 80.84 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115238531..115261087, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115347705..115367756, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene otopetrin 2 Neighboring gene USH1 protein network component sans Neighboring gene STARR-seq mESC enhancer starr_31156 Neighboring gene otopetrin 3 Neighboring gene predicted gene, 53654 Neighboring gene cerebellar degeneration-related protein 2-like Neighboring gene predicted gene, 32013

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HID-1 is required for homotypic fusion of immature secretory granules during maturation. Du W, et al. Elife, 2016 Oct 18. PMID 27751232, Free PMC Article
    2. Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Kikkawa Y, et al. Hum Mol Genet, 2003 Mar 1. PMID 12588793
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi medial cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi medial cisterna ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in Golgi trans cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi trans cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi trans cisterna ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein HID1
    Names
    HID1 domain-containing protein
    UPF0663 transmembrane protein C17orf28 homolog
    protein hid-1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346774.1 → NP_001333703.1  protein HID1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK138882, AL603828, AW047036, CJ153052
      Consensus CDS
      CCDS83927.1
      UniProtKB/TrEMBL
      Q3UU20
      Related
      ENSMUSP00000043789.7, ENSMUST00000044152.13

    2. NM_175454.2 → NP_780663.1  protein HID1 isoform 1

      See identical proteins and their annotated locations for NP_780663.1

      Status: VALIDATED

      Source sequence(s)
      AL603828
      Consensus CDS
      CCDS25630.1
      UniProtKB/Swiss-Prot
      A2A6S8, Q8C8V6, Q8R1F6
      Related
      ENSMUSP00000102152.3, ENSMUST00000106542.9
      Conserved Domains (1) summary
      pfam12722
      Location:1 → 785
      Hid1; High-temperature-induced dauer-formation protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115238531..115261087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314488.3 → XP_017169977.1  protein HID1 isoform X1

      Conserved Domains (1) summary
      cl15483
      Location:2 → 584
      Hid1; High-temperature-induced dauer-formation protein

    2. XM_030245892.2 → XP_030101752.1  protein HID1 isoform X1

      Conserved Domains (1) summary
      cl15483
      Location:2 → 584
      Hid1; High-temperature-induced dauer-formation protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1F6.1 GenPept UniProtKB/Swiss-Prot:Q8R1F6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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