Cacng8 calcium channel, voltage-dependent, gamma subunit 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacng8provided by MGI
Official Full Name: calcium channel, voltage-dependent, gamma subunit 8provided by MGI
Primary source: MGI:MGI:1932376
See related: Ensembl:ENSMUSG00000053395 AllianceGenome:MGI:1932376
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables calcium channel regulator activity. Involved in regulation of AMPA receptor activity and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in postsynaptic density. Part of L-type voltage-gated calcium channel complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system and retina. Used to study antisocial personality disorder. Orthologous to human CACNG8 (calcium voltage-gated channel auxiliary subunit gamma 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 16.4), cortex adult (RPKM 14.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 1.98 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3442558..3464782)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3394042..3416266)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of transmembrane AMPA receptor regulatory protein gamma-8 leads to attention-deficit hyperactivity disorder-like behavior in mice.
Title: Deficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice.
Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Title: Gating and modulation of a hetero-octameric AMPA glutamate receptor.
AMPA receptor auxiliary subunit TARP gamma-8, via its PDZ-binding motif, is indispensable for both basal synaptic transmission and Long-term potentiation.
Title: LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.
Critically, by altering the two interacting loops of TARP gamma2 and TARP gamma8, the authors could entirely remove all allosteric modulation of GluA2, without affecting formation of AMPA receptor-TARP complexes.
Title: Control of AMPA receptor activity by the extracellular loops of auxiliary proteins.
these findings demonstrate that TARPgamma-8 is a crucial mediator of CaMKII-dependent Long Term Potentiation and therefore a molecular target that controls synaptic plasticity and associated cognitive functions.
Title: CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory.
TARP gamma-8 is the only TARP expressed at nonperforated type of pyramidal cell synapses, playing an essential role in low-density or basal AMPAR expression
Title: TARP γ-2 and γ-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area.
This study demonstrated that genetic inactivation of this specific population of AMPA receptors results in modest changes in behavior characterized by a mild hyperactivity.
Title: Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§.
coexpression of both auxiliary subunits,CKAMP44 and TARP gamma-8 is necessary for the efficient targeting of AMPARs to the cell surface of dentate gyrus granule cells
Title: Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function.
The results of thia study suggested that there are distinct TARP-dependent mechanisms for synaptic transmission and long term potential.
Title: PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity.
Tarp gamma-8 (and CNIH-2) functionally interact with common AMPA receptor complexes in hippocampus; however, TARP gamma-8-containing hippocampal neurons do not display resensitization.
Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of AMPA receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info
involved_in transmission of nerve impulse	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of AMPA glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
part_of L-type voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent calcium channel gamma-8 subunit

Names: TARP gamma-8; neuronal voltage-gated calcium channel gamma-8 subunit; transmembrane AMPAR regulatory protein gamma-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133190.3 → NP_573453.2 voltage-dependent calcium channel gamma-8 subunit

Status: VALIDATED

Source sequence(s)

AC217111

Consensus CDS

CCDS57471.1

UniProtKB/Swiss-Prot

Q8VHW2

UniProtKB/TrEMBL

F7CZ64, S4R2F1

Related

ENSMUSP00000090005.6, ENSMUST00000092351.6

Conserved Domains (1) summary

cl21598
Location:17 → 222

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family