Tmem14c transmembrane protein 14C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem14cprovided by MGI
Official Full Name: transmembrane protein 14Cprovided by MGI
Primary source: MGI:MGI:1913404
See related: Ensembl:ENSMUSG00000021361 AllianceGenome:MGI:1913404
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HSPC194; 1110021D01Rik
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; mitochondrial transport; and regulation of heme biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; hemolymphoid system; salivary gland primordium; sensory organ; and skeletal muscle. Orthologous to several human genes including TMEM14C (transmembrane protein 14C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 150.0), liver E14.5 (RPKM 146.6) and 27 other tissues See more
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Genomic context

Location:: 13 A3.3; 13 20.25 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (41169726..41176058)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (41016250..41022582)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM14C facilitates the import of protoporphyrinogen IX into the mitochondrial matrix for heme synthesis and subsequent hemoglobin production
Title: TMEM14C is required for erythroid mitochondrial heme metabolism.
Required for functional heme biosynthesis in erythroid cells.
Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitrogen compound transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane protein 14C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360770.1 → NP_001347699.1 transmembrane protein 14C isoform 2

Status: VALIDATED

Source sequence(s)

AC133496

UniProtKB/TrEMBL

Q8C297

Conserved Domains (1) summary

pfam03647
Location:5 → 94

Tmemb_14; Transmembrane proteins 14C
NM_025387.3 → NP_079663.1 transmembrane protein 14C isoform 1

See identical proteins and their annotated locations for NP_079663.1

Status: VALIDATED

Source sequence(s)

AK010609, BY785978, CO039120

Consensus CDS

CCDS26470.1

UniProtKB/Swiss-Prot

Q543H6, Q9CQN6, Q9D849

Related

ENSMUSP00000021790.6, ENSMUST00000021790.7

Conserved Domains (1) summary

pfam03647
Location:13 → 102

Tmemb_14; Transmembrane proteins 14C