Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asap1provided by MGI
Official Full Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1provided by MGI
Primary source: MGI:MGI:1342335
See related: Ensembl:ENSMUSG00000022377 AllianceGenome:MGI:1342335
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAP; s19; DEF-1; Ddef1; mKIAA1249
Summary: Enables GTPase activator activity and phospholipid binding activity. Involved in regulation of postsynapse organization. Acts upstream of or within negative regulation of dendritic spine development and positive regulation of membrane tubulation. Located in dendritic spine and podosome. Is active in glutamatergic synapse. Is expressed in several structures, including gonad; hemolymphoid system; limb; long bone; and nervous system. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 21.3), cortex adult (RPKM 15.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 28.55 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (63958704..64254922, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (64086840..64382941, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
Together these observations suggest that ASAP1 plays a decisive role during the differentiation of mesenchymal progenitor cells
Title: Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.
these data indicated that ribosomal protein S19 polymer plays the roles in the early erythroblast differentiation of C57BL/6J mouse spleen
Title: Erythroblast differentiation at spleen in Q137E mutant ribosomal protein S19 gene knock-in C57BL/6J mice.
results support the hypothesis that ASAP1 is a positive regulator of NM2A.
Title: The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.
we demonstrate that Prox1 and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
Title: A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1.
ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein Arf4 & the 2 G proteins of the Rab family--Rab11 & Rab8--linked by the Rab8 guanine nucleotide exchange factor Rabin8.
Title: The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting.
ASAP1 was suggested to negatively regulate lipopolysaccharide (LPS)-induced proinflammatory mediators production through down-regulating LPS signaling
Title: An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide.
ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
Title: ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
ASAP1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain and phosphorylation by Src.
Title: Src-dependent phosphorylation of ASAP1 regulates podosomes.
DEF-1 alters cell motility through the deactivation of ARF1. In contrast, the inhibition of cell spreading by DEF-1 was not dependent on GAP activity, indicating that spreading and motility are altered by DEF-1 through different pathways.
Title: DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498229 (e-PCR)
- UniSTS:498229

Ddef1 (e-PCR), detects polymorphism
- UniSTS:498229

RH131168 (e-PCR)
- UniSTS:214451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of dendritic spine development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of membrane tubulation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in podosome	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Names: 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; PIP2-dependent ARF1 GAP; development and differentiation-enhancing factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276461.2 → NP_001263390.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AC098728, AC131710, AC156573

Consensus CDS

CCDS70633.1

UniProtKB/TrEMBL

H3BKE6, Q3UJA5

Related

ENSMUSP00000135359.2, ENSMUST00000175799.8

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1029 → 1085

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:739 → 1018

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:328 → 434

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:613 → 646

ANK; ANK repeat [structural motif]

cd08848
Location:449 → 570

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:617 → 689

Ank_2; Ankyrin repeats (3 copies)
NM_001276462.2 → NP_001263391.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC131710, AC156573

Consensus CDS

CCDS70631.1

UniProtKB/TrEMBL

E9QN63, H3BL41

Related

ENSMUSP00000135643.2, ENSMUST00000177371.8

Conserved Domains (7) summary

cd07641
Location:34 → 248

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1066 → 1122

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:717 → 1055

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:308 → 414

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:593 → 626

ANK; ANK repeat [structural motif]

cd08848
Location:429 → 550

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:597 → 669

Ank_2; Ankyrin repeats (3 copies)
NM_001276463.2 → NP_001263392.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream start codon, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AC131710, AC156573

Consensus CDS

CCDS70632.1

UniProtKB/TrEMBL

E9QMJ1, E9QN63

Related

ENSMUSP00000134877.2, ENSMUST00000177083.8

Conserved Domains (7) summary

cd07641
Location:34 → 248

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1054 → 1110

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:705 → 1043

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:296 → 402

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:581 → 614

ANK; ANK repeat [structural motif]

cd08848
Location:417 → 538

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:585 → 657

Ank_2; Ankyrin repeats (3 copies)
NM_001276467.2 → NP_001263396.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.

Source sequence(s)

AC098728, AC131710, AC156573

Consensus CDS

CCDS70634.1

UniProtKB/TrEMBL

E9QMI7

Related

ENSMUSP00000135190.2, ENSMUST00000176384.8

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1032 → 1088

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:742 → 1021

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:331 → 437

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:616 → 649

ANK; ANK repeat [structural motif]

cd08848
Location:452 → 573

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:620 → 692

Ank_2; Ankyrin repeats (3 copies)
NM_001411185.1 → NP_001398114.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform f

Status: VALIDATED

Source sequence(s)

AC098728, AC131710, AC156573

Related

ENSMUSP00000105742.3, ENSMUST00000110115.9
NM_010026.4 → NP_034156.2 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform a

See identical proteins and their annotated locations for NP_034156.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC098728, AC131710, AC156573

Consensus CDS

CCDS56986.1

UniProtKB/Swiss-Prot

O08612, Q505F0, Q80TG8, Q80UV6, Q99LV8, Q9QWY8, Q9Z2B6

UniProtKB/TrEMBL

E9QN63

Related

ENSMUSP00000134825.2, ENSMUST00000177374.8

Conserved Domains (9) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1089 → 1145

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

cd00204
Location:616 → 704

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13251
Location:331 → 437

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

pfam00169
Location:341 → 426

PH; PH domain

pfam01412
Location:454 → 570

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:597 → 682

Ank_2; Ankyrin repeats (3 copies)

pfam16638
Location:931 → 1013

Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers

sd00045
Location:616 → 649

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

63958704..64254922 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159121.1 → XP_036015014.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

UniProtKB/TrEMBL

H3BKD4, Q3UJA5

Related

ENSMUSP00000135346.2, ENSMUST00000177035.8

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1017 → 1073

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:727 → 1006

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:316 → 422

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:601 → 634

ANK; ANK repeat [structural motif]

cd08848
Location:437 → 558

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:605 → 677

Ank_2; Ankyrin repeats (3 copies)
XM_036159120.1 → XP_036015013.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

UniProtKB/TrEMBL

E9QMI7

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1020 → 1076

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:730 → 1009

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:319 → 425

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:604 → 637

ANK; ANK repeat [structural motif]

cd08848
Location:440 → 561

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:608 → 680

Ank_2; Ankyrin repeats (3 copies)
XM_036159117.1 → XP_036015010.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

UniProtKB/TrEMBL

E9QN63

Related

ENSMUSP00000135718.2, ENSMUST00000175793.8

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1077 → 1133

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:728 → 1066

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:319 → 425

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:604 → 637

ANK; ANK repeat [structural motif]

cd08848
Location:440 → 561

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:608 → 680

Ank_2; Ankyrin repeats (3 copies)
XM_036159116.1 → XP_036015009.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

UniProtKB/TrEMBL

E9QN63, H3BJY2

Related

ENSMUSP00000135172.2, ENSMUST00000176014.8

Conserved Domains (7) summary

cd07641
Location:54 → 268

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1086 → 1142

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:737 → 1075

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:328 → 434

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:613 → 646

ANK; ANK repeat [structural motif]

cd08848
Location:449 → 570

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:617 → 689

Ank_2; Ankyrin repeats (3 copies)
XM_036159119.1 → XP_036015012.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

UniProtKB/TrEMBL

E9QN63

Conserved Domains (7) summary

cd11965
Location:1030 → 1086

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:681 → 1019

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:272 → 378

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:557 → 590

ANK; ANK repeat [structural motif]

cd08848
Location:393 → 514

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:561 → 633

Ank_2; Ankyrin repeats (3 copies)

cl12013
Location:1 → 209

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006520395.2 → XP_006520458.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

UniProtKB/TrEMBL

E9QN63

Conserved Domains (7) summary

cd07641
Location:138 → 344

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1150 → 1206

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

cd13251
Location:392 → 498

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:677 → 710

ANK; ANK repeat [structural motif]

cd08848
Location:513 → 634

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam03154
Location:830 → 1094

Atrophin-1; Atrophin-1 family

pfam12796
Location:681 → 753

Ank_2; Ankyrin repeats (3 copies)
XM_006520394.2 → XP_006520457.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

E9QN63

Conserved Domains (7) summary

cd07641
Location:138 → 344

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1153 → 1209

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

cd13251
Location:395 → 501

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:680 → 713

ANK; ANK repeat [structural motif]

cd08848
Location:516 → 637

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam03154
Location:833 → 1097

Atrophin-1; Atrophin-1 family

pfam12796
Location:684 → 756

Ank_2; Ankyrin repeats (3 copies)
XM_036159115.1 → XP_036015008.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

UniProtKB/TrEMBL

Q3UJA5

Conserved Domains (7) summary

cd11965
Location:1105 → 1161

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:815 → 1094

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:404 → 510

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:689 → 722

ANK; ANK repeat [structural motif]

cd08848
Location:525 → 646

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:693 → 765

Ank_2; Ankyrin repeats (3 copies)

cl12013
Location:138 → 344

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006520393.2 → XP_006520456.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

E9QN63

Conserved Domains (7) summary

cd07641
Location:138 → 344

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1162 → 1218

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

cd13251
Location:404 → 510

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:689 → 722

ANK; ANK repeat [structural motif]

cd08848
Location:525 → 646

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam03154
Location:842 → 1106

Atrophin-1; Atrophin-1 family

pfam12796
Location:693 → 765

Ank_2; Ankyrin repeats (3 copies)
XM_006520397.2 → XP_006520460.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

UniProtKB/TrEMBL

E9QMI7

Conserved Domains (7) summary

cd11965
Location:1108 → 1164

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:818 → 1097

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:407 → 513

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:692 → 725

ANK; ANK repeat [structural motif]

cd08848
Location:528 → 649

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:696 → 768

Ank_2; Ankyrin repeats (3 copies)

cl12013
Location:138 → 344

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006520392.2 → XP_006520455.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

E9QN63

Conserved Domains (7) summary

cd07641
Location:138 → 344

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1165 → 1221

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

cd13251
Location:407 → 513

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:692 → 725

ANK; ANK repeat [structural motif]

cd08848
Location:528 → 649

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam03154
Location:845 → 1109

Atrophin-1; Atrophin-1 family

pfam12796
Location:696 → 768

Ank_2; Ankyrin repeats (3 copies)
XM_036159118.1 → XP_036015011.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

UniProtKB/TrEMBL

E9QN63

Conserved Domains (7) summary

cd07641
Location:34 → 248

BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1

cd11965
Location:1069 → 1125

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

PHA03247
Location:720 → 1058

PHA03247; large tegument protein UL36; Provisional

cd13251
Location:311 → 417

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:596 → 629

ANK; ANK repeat [structural motif]

cd08848
Location:432 → 553

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam12796
Location:600 → 672

Ank_2; Ankyrin repeats (3 copies)
XM_011245448.1 → XP_011243750.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

UniProtKB/TrEMBL

E9QN63

Conserved Domains (7) summary

cd11965
Location:1038 → 1094

SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1

cd13251
Location:280 → 386

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:565 → 598

ANK; ANK repeat [structural motif]

cd08848
Location:401 → 522

ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)

pfam03154
Location:718 → 982

Atrophin-1; Atrophin-1 family

pfam12796
Location:569 → 641

Ank_2; Ankyrin repeats (3 copies)

cl12013
Location:12 → 217

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature