Rnasek ribonuclease, RNase K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnasekprovided by MGI
Official Full Name: ribonuclease, RNase Kprovided by MGI
Primary source: MGI:MGI:106369
See related: Ensembl:ENSMUSG00000093989 AllianceGenome:MGI:106369
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D11Bwg0434e; 2310033H11Rik
Summary: Predicted to enable RNA endonuclease activity. Predicted to be involved in endosomal lumen acidification; proton transmembrane transport; and receptor-mediated endocytosis of virus by host cell. Predicted to be located in membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Is expressed in cranial ganglion; dorsal root ganglion; neural retina; and pancreas epithelium. Orthologous to human RNASEK (ribonuclease K). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 136.6), adrenal adult (RPKM 115.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70128949..70130678, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70238123..70239852, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2)

General gene information

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Markers

MARC_13791-13792:1006807790:1 (e-PCR)
- UniSTS:267556

RH124254 (e-PCR)
- UniSTS:161076

MARC_24292-24293:1030106971:1 (e-PCR)
- UniSTS:268876

D11Bwg0434e (e-PCR), detects polymorphism
- UniSTS:141718

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endosomal lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in endosomal lumen acidification	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis of virus by host cell	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis of virus by host cell	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ribonuclease kappa

Names: RNase K; RNase kappa; V-ATPase subunit f; V-type proton ATPase subunit f

NP_776103.1

EC 3.1.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.