Ppox protoporphyrinogen oxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppoxprovided by MGI
Official Full Name: protoporphyrinogen oxidaseprovided by MGI
Primary source: MGI:MGI:104968
See related: Ensembl:ENSMUSG00000062729 AllianceGenome:MGI:104968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ppo
Summary: Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within heme biosynthetic process. Located in mitochondrial inner membrane. Is active in mitochondrial intermembrane space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 89.8), liver E14 (RPKM 78.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.3 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171104564..171108955, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171276991..171281193, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

isolation, characterization and localization of gene.
Title: Characterization of the mouse protoporphyrinogen oxidase gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppox (e-PCR), detects polymorphism
- UniSTS:507170

AW125175 (e-PCR)
- UniSTS:178515

Ppox (e-PCR), detects polymorphism
- UniSTS:144255

RH128542 (e-PCR)
- UniSTS:211850

D1S3691 (e-PCR)
- UniSTS:474269

W53272 (e-PCR), detects polymorphism
- UniSTS:143014

RH125138 (e-PCR)
- UniSTS:161960

RH64578 (e-PCR)
- UniSTS:32953

G43283 (e-PCR)
- UniSTS:94919

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables menaquinone-dependent protoporphyrinogen oxidase activity	IEA Inferred from Electronic Annotation more info
enables oxygen-dependent protoporphyrinogen oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen-dependent protoporphyrinogen oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxygen-dependent protoporphyrinogen oxidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in heme A biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heme B biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heme O biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in porphyrin-containing compound biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in porphyrin-containing compound biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: protoporphyrinogen oxidase

Names: protoporhyrinogen oxidase

NP_032937.1

EC 1.3.3.4

XP_006496770.1

EC 1.3.3.4

XP_006496772.1

EC 1.3.3.4

XP_011237074.1

EC 1.3.3.4

XP_011237075.1

EC 1.3.3.4

XP_030108150.1

EC 1.3.3.4

XP_030108151.1

EC 1.3.3.4

XP_030108152.1

EC 1.3.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008911.2 → NP_032937.1 protoporphyrinogen oxidase

See identical proteins and their annotated locations for NP_032937.1

Status: VALIDATED

Source sequence(s)

AC084821, AK142632, U25114

Consensus CDS

CCDS15487.1

UniProtKB/Swiss-Prot

P51175, P97344, Q99M34

UniProtKB/TrEMBL

Q3UQA3

Related

ENSMUSP00000072863.5, ENSMUST00000073120.11

Conserved Domains (1) summary

TIGR00562
Location:3 → 471

proto_IX_ox; protoporphyrinogen oxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

171104564..171108955 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496707.4 → XP_006496770.1 protoporphyrinogen oxidase isoform X1

See identical proteins and their annotated locations for XP_006496770.1

UniProtKB/Swiss-Prot

P51175, P97344, Q99M34

UniProtKB/TrEMBL

Q3UQA3

Conserved Domains (1) summary

TIGR00562
Location:3 → 471

proto_IX_ox; protoporphyrinogen oxidase
XM_030252290.1 → XP_030108150.1 protoporphyrinogen oxidase isoform X3

UniProtKB/TrEMBL

Q3UQA3

Conserved Domains (1) summary

TIGR00562
Location:3 → 388

proto_IX_ox; protoporphyrinogen oxidase
XM_011238773.3 → XP_011237075.1 protoporphyrinogen oxidase isoform X2

See identical proteins and their annotated locations for XP_011237075.1

UniProtKB/TrEMBL

Q3UQA3

Conserved Domains (1) summary

TIGR00562
Location:18 → 427

proto_IX_ox; protoporphyrinogen oxidase
XM_030252292.1 → XP_030108152.1 protoporphyrinogen oxidase isoform X4

Conserved Domains (1) summary

TIGR00562
Location:4 → 309

proto_IX_ox; protoporphyrinogen oxidase
XM_030252291.1 → XP_030108151.1 protoporphyrinogen oxidase isoform X4

Conserved Domains (1) summary

TIGR00562
Location:4 → 309

proto_IX_ox; protoporphyrinogen oxidase
XM_011238772.3 → XP_011237074.1 protoporphyrinogen oxidase isoform X2

See identical proteins and their annotated locations for XP_011237074.1

UniProtKB/TrEMBL

Q3UQA3

Conserved Domains (1) summary

TIGR00562
Location:18 → 427

proto_IX_ox; protoporphyrinogen oxidase
XM_006496709.5 → XP_006496772.1 protoporphyrinogen oxidase isoform X3

UniProtKB/TrEMBL

Q3UQA3

Conserved Domains (1) summary

TIGR00562
Location:3 → 388

proto_IX_ox; protoporphyrinogen oxidase