Nxf3 nuclear RNA export factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nxf3provided by MGI
Official Full Name: nuclear RNA export factor 3provided by MGI
Primary source: MGI:MGI:2685230
See related: Ensembl:ENSMUSG00000057000 AllianceGenome:MGI:2685230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm384
Summary: Enables mRNA binding activity. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in cytoplasm. Is expressed in testis. Orthologous to human NXF3 (nuclear RNA export factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 20.5) and genital fat pad adult (RPKM 12.4) See more
Orthologs: human all
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Genomic context

Location:: X F1; X 57.38 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (134972272..135040382, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (136071523..136139579, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

evidence of a new role for NXF3 in regulating the distribution of snoRNAs between the nuclear and cytoplasmic compartments.
Title: Nuclear export factor 3 regulates localization of small nucleolar RNAs.
Mechanistic insights into the roles of NXF3 are implicated in transforming growth factor (TGF)-beta-mediated expression of Tgfbeta3 and other genes.
Title: Nuclear export factor 3 is involved in regulating the expression of TGF-β3 in an mRNA export activity-independent manner in mouse Sertoli cells.
The Nxf3 is expressed exclusively in Sertoli cells of the postnatal testis, in a developmentally regulated manner.
Title: Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of nuclear RNA export factor complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear RNA export factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024141.4 → NP_001019312.1 nuclear RNA export factor 3

See identical proteins and their annotated locations for NP_001019312.1

Status: VALIDATED

Source sequence(s)

AL671914

Consensus CDS

CCDS41132.1

UniProtKB/TrEMBL

Q4ZGD9

Related

ENSMUSP00000079730.7, ENSMUST00000080929.13

Conserved Domains (4) summary

smart00804
Location:485 → 547

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:192 → 230

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:99 → 178

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:314 → 470

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

134972272..135040382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161963.1 → XP_036017856.1 nuclear RNA export factor 3 isoform X3

Conserved Domains (4) summary

smart00804
Location:486 → 548

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:193 → 231

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:86 → 168

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:315 → 471

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_030251344.1 → XP_030107204.1 nuclear RNA export factor 3 isoform X1

Conserved Domains (4) summary

smart00804
Location:499 → 561

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:206 → 244

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:99 → 181

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:328 → 484

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_006528531.3 → XP_006528594.2 nuclear RNA export factor 3 isoform X2

See identical proteins and their annotated locations for XP_006528594.2

Conserved Domains (4) summary

smart00804
Location:493 → 555

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:200 → 238

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:93 → 175

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:322 → 478

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_011247739.2 → XP_011246041.1 nuclear RNA export factor 3 isoform X2

See identical proteins and their annotated locations for XP_011246041.1

Conserved Domains (4) summary

smart00804
Location:493 → 555

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:200 → 238

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:93 → 175

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:322 → 478

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_011247740.2 → XP_011246042.1 nuclear RNA export factor 3 isoform X3

See identical proteins and their annotated locations for XP_011246042.1

Conserved Domains (4) summary

smart00804
Location:486 → 548

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:193 → 231

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:86 → 168

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:315 → 471

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_006528534.3 → XP_006528597.2 nuclear RNA export factor 3 isoform X3

See identical proteins and their annotated locations for XP_006528597.2

Conserved Domains (4) summary

smart00804
Location:486 → 548

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:193 → 231

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:86 → 168

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:315 → 471

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_006528532.3 → XP_006528595.2 nuclear RNA export factor 3 isoform X3

See identical proteins and their annotated locations for XP_006528595.2

Conserved Domains (4) summary

smart00804
Location:486 → 548

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:193 → 231

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:86 → 168

Tap-RNA_bind; Tap, RNA-binding

cl09109
Location:315 → 471

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
XM_006528536.5 → XP_006528599.1 nuclear RNA export factor 3 isoform X4

Conserved Domains (1) summary

pfam09162
Location:99 → 181

Tap-RNA_bind; Tap, RNA-binding