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    Tas1r3 taste receptor, type 1, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 83771, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tas1r3provided by MGI
    Official Full Name
    taste receptor, type 1, member 3provided by MGI
    Primary source
    MGI:MGI:1933547
    See related
    Ensembl:ENSMUSG00000029072 AllianceGenome:MGI:1933547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sac; T1r3
    Summary
    Predicted to enable G protein-coupled receptor activity and taste receptor activity. Predicted to contribute to sweet taste receptor activity. Acts upstream of or within sensory perception of sweet taste. Predicted to be located in Golgi apparatus. Predicted to be part of sweet taste receptor complex. Predicted to be active in plasma membrane. Is expressed in circumvallate papillae and tongue anterior part. Orthologous to human TAS1R3 (taste 1 receptor member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 1.6), thymus adult (RPKM 1.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tas1r3 in Genome Data Viewer
    Location:
    4 E2; 4 87.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155943725..155947810, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155859268..155863353, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4740 Neighboring gene STARR-positive B cell enhancer ABC_E8042 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10297 Neighboring gene matrix-remodelling associated 8 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridylate synthase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. T1R3 taste receptor is critical for sucrose but not Polycose taste. Zukerman S, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Apr. PMID 19091911, Free PMC Article
    2. Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction. Martin B, et al. J Biol Chem, 2017 Jul 7. PMID 28522608, Free PMC Article
    3. Metabotropic glutamate receptors are involved in the detection of IMP and L-amino acids by mouse taste sensory cells. Pal Choudhuri S, et al. Neuroscience, 2016 Mar 1. PMID 26701297
    4. Muscle regulatory factors regulate T1R3 taste receptor expression. Kokabu S, et al. Biochem Biophys Res Commun, 2015 Dec 25. PMID 26545778
    5. L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors. Pal Choudhuri S, et al. PLoS One, 2015. PMID 26110622, Free PMC Article

    See all (133) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3.
      Title: Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3.
    2. Taste receptor type 1 member 3 mediates diet-induced cognitive impairment in mice.
      Title: Taste receptor type 1 member 3 mediates diet-induced cognitive impairment in mice.
    3. Taste receptor type 1 member 3 enables western diet-induced anxiety in mice.
      Title: Taste receptor type 1 member 3 enables western diet-induced anxiety in mice.
    4. Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
      Title: Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
    5. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
      Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
    6. Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE(-/-) mice.
      Title: Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE(-/-) mice.
    7. Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.
      Title: Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.
    8. TAS1R3 is not required to mount an immune response to the helminth Heligmosomoides polygyrus, which infects the proximal small intestine. Examination of uninfected Tas1r3(-/-) mice revealed a modest reduction in the number of tuft cells in the proximal small intestine but a severe decrease in the distal small intestine at homeostasis.
      Title: The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis.
    9. this study shows that taste receptor T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells
      Title: Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells.
    10. residual sensitivity by the T1R1+T1R3 KO mice demonstrates that a T1R-independent mechanism can contribute to the detectability of high concentrations of this prototypical umami compound stimulus
      Title: Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (69)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to sweet taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sweet taste receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to sweet taste receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to taste receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables taste receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of sweet taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of sweet taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sweet taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of sweet taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of sweet taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of umami taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of umami taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of umami taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of sweet taste receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sweet taste receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 1 member 3
    Names
    saccharin preference protein
    sweet taste receptor T1R3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031872.2 → NP_114078.1  taste receptor type 1 member 3 precursor

      See identical proteins and their annotated locations for NP_114078.1

      Status: PROVISIONAL

      Source sequence(s)
      AL670236
      Consensus CDS
      CCDS19046.1
      UniProtKB/Swiss-Prot
      A2ADA0, Q91VA4, Q923K0, Q925A4, Q925D8, Q925D9
      Related
      ENSMUSP00000030949.4, ENSMUST00000030949.4
      Conserved Domains (4) summary
      pfam00003
      Location:597 → 821
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:73 → 469
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:501 → 551
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:29 → 494
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155943725..155947810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925D8.2 GenPept UniProtKB/Swiss-Prot:Q925D8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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