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    Snx18 sorting nexin 18 [ Mus musculus (house mouse) ]

    Gene ID: 170625, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Snx18provided by MGI
    Official Full Name
    sorting nexin 18provided by MGI
    Primary source
    MGI:MGI:2137642
    See related
    Ensembl:ENSMUSG00000042364 AllianceGenome:MGI:2137642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snag1
    Summary
    Enables phosphatidylinositol binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; plasma membrane tubulation; and positive regulation of autophagosome assembly. Located in growth cone and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SNX18 (sorting nexin 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 28.8), bladder adult (RPKM 12.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx18 in Genome Data Viewer
    Location:
    13 D2.2; 13 64.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113728715..113755100, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (113592179..113618564, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921509O07 gene Neighboring gene predicted gene, 31191 Neighboring gene predicted gene, 34471 Neighboring gene STARR-seq mESC enhancer starr_35712 Neighboring gene predicted gene, 53817 Neighboring gene predicted gene, 34528 Neighboring gene STARR-seq mESC enhancer starr_35713 Neighboring gene STARR-seq mESC enhancer starr_35714 Neighboring gene STARR-seq mESC enhancer starr_35715 Neighboring gene STARR-seq mESC enhancer starr_35719 Neighboring gene STARR-seq mESC enhancer starr_35720 Neighboring gene STARR-positive B cell enhancer mm9_chr13:114408812-114409113 Neighboring gene STARR-positive B cell enhancer mm9_chr13:114429053-114429354 Neighboring gene predicted gene, 34586 Neighboring gene STARR-seq mESC enhancer starr_35726 Neighboring gene heat shock protein 3 Neighboring gene predicted gene, 53818 Neighboring gene STARR-seq mESC enhancer starr_35729 Neighboring gene STARR-seq mESC enhancer starr_35731

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. Thornhill PB, et al. FEBS Lett, 2007 Sep 18. PMID 17761170
    2. Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons. Nakazawa S, et al. J Histochem Cytochem, 2011 Feb. PMID 21339182, Free PMC Article
    3. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. Zhang D, et al. CNS Neurosci Ther, 2023 Oct. PMID 37072933, Free PMC Article
    4. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    5. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNX18 may play an active role in axonal elongation
      Title: Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-18
    Names
    sorting nexin associated golgi protein 1
    sorting nexin-associated Golgi protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130796.4 → NP_570614.2  sorting nexin-18

      See identical proteins and their annotated locations for NP_570614.2

      Status: VALIDATED

      Source sequence(s)
      BC063089, BC137801, BP763454
      Consensus CDS
      CCDS36784.1
      UniProtKB/Swiss-Prot
      Q91ZR2
      UniProtKB/TrEMBL
      Q8C788
      Related
      ENSMUSP00000104864.4, ENSMUST00000109241.5
      Conserved Domains (3) summary
      cd07286
      Location:267 → 394
      PX_SNX18; The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
      cd07670
      Location:406 → 612
      BAR_SNX18; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 18
      cd11897
      Location:4 → 58
      SH3_SNX18; Src Homology 3 domain of Sorting nexin 18

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      113728715..113755100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZR2.1 GenPept UniProtKB/Swiss-Prot:Q91ZR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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