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    Zfp583 zinc finger protein 583 [ Mus musculus (house mouse) ]

    Gene ID: 213011, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp583provided by MGI
    Official Full Name
    zinc finger protein 583provided by MGI
    Primary source
    MGI:MGI:2682297
    See related
    Ensembl:ENSMUSG00000030443 AllianceGenome:MGI:2682297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf583
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF583 (zinc finger protein 583). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.4), CNS E14 (RPKM 1.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp583 in Genome Data Viewer
    Location:
    7 A1; 7 3.66 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6313130..6335954, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6310131..6332955, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17972 Neighboring gene epididymal protein 13 Neighboring gene STARR-positive B cell enhancer ABC_E11341 Neighboring gene STARR-seq mESC enhancer starr_17975 Neighboring gene STARR-positive B cell enhancer ABC_E4894 Neighboring gene zinc finger protein 667 Neighboring gene predicted gene, 38944 Neighboring gene zinc finger protein 582 Neighboring gene STARR-positive B cell enhancer ABC_E8944 Neighboring gene STARR-positive B cell enhancer ABC_E442 Neighboring gene STARR-seq mESC enhancer starr_17978 Neighboring gene zinc finger protein 78 Neighboring gene predicted gene, 53349

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 583

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033249.3 → NP_001028421.1  zinc finger protein 583

      See identical proteins and their annotated locations for NP_001028421.1

      Status: VALIDATED

      Source sequence(s)
      AC148989, AK133380, AV174083
      Consensus CDS
      CCDS39751.1
      UniProtKB/Swiss-Prot
      Q3V080, Q3V3L4
      Related
      ENSMUSP00000104200.2, ENSMUST00000108560.8
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:200 → 541
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6313130..6335954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242340.1 → XP_030098200.1  zinc finger protein 583 isoform X7

      UniProtKB/Swiss-Prot
      Q3V080, Q3V3L4
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:200 → 541
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011250475.3 → XP_011248777.1  zinc finger protein 583 isoform X7

      See identical proteins and their annotated locations for XP_011248777.1

      UniProtKB/Swiss-Prot
      Q3V080, Q3V3L4
      Related
      ENSMUSP00000053935.8, ENSMUST00000062765.14
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:200 → 541
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030242339.2 → XP_030098199.1  zinc finger protein 583 isoform X5

      Conserved Domains (3) summary
      smart00349
      Location:38 → 98
      KRAB; krueppel associated box
      COG5048
      Location:232 → 573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:273 → 293
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_011250474.4 → XP_011248776.1  zinc finger protein 583 isoform X6

      See identical proteins and their annotated locations for XP_011248776.1

      Conserved Domains (3) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:201 → 542
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:242 → 262
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_011250473.4 → XP_011248775.1  zinc finger protein 583 isoform X6

      See identical proteins and their annotated locations for XP_011248775.1

      Conserved Domains (3) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:201 → 542
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:242 → 262
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_011250469.3 → XP_011248771.1  zinc finger protein 583 isoform X3

      See identical proteins and their annotated locations for XP_011248771.1

      Conserved Domains (3) summary
      smart00349
      Location:38 → 99
      KRAB; krueppel associated box
      COG5048
      Location:233 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_011250472.3 → XP_011248774.1  zinc finger protein 583 isoform X4

      Conserved Domains (3) summary
      smart00349
      Location:37 → 98
      KRAB; krueppel associated box
      COG5048
      Location:232 → 573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:273 → 293
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_011250468.3 → XP_011248770.1  zinc finger protein 583 isoform X3

      See identical proteins and their annotated locations for XP_011248770.1

      Conserved Domains (3) summary
      smart00349
      Location:38 → 99
      KRAB; krueppel associated box
      COG5048
      Location:233 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_030242338.1 → XP_030098198.1  zinc finger protein 583 isoform X2

      Conserved Domains (3) summary
      smart00349
      Location:45 → 105
      KRAB; krueppel associated box
      COG5048
      Location:239 → 580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. XM_030242337.1 → XP_030098197.1  zinc finger protein 583 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:45 → 106
      KRAB; krueppel associated box
      COG5048
      Location:240 → 581
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_011250470.4 → XP_011248772.1  zinc finger protein 583 isoform X3

      See identical proteins and their annotated locations for XP_011248772.1

      Conserved Domains (3) summary
      smart00349
      Location:38 → 99
      KRAB; krueppel associated box
      COG5048
      Location:233 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V080.1 GenPept UniProtKB/Swiss-Prot:Q3V080

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