Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naa15provided by MGI
Official Full Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunitprovided by MGI
Primary source: MGI:MGI:1922088
See related: Ensembl:ENSMUSG00000063273 AllianceGenome:MGI:1922088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Narg1; mNAT1; ASTBDN; Tbdn-1; 6330400I15; 5730450D16Rik
Summary: Enables N-acetyltransferase activity. Predicted to be involved in several processes, including N-terminal protein amino acid acetylation; positive regulation of DNA-templated transcription; and protein stabilization. Located in cytoplasm. Is expressed in several structures, including brain; cornea endothelium; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 15.4), placenta adult (RPKM 10.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 22.47 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (51323437..51383406)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (51416016..51475985)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, these results show that Naa15 regulates myotome formation and myogenesis
Title: Naa15 knockdown enhances c2c12 myoblast fusion and induces defects in zebrafish myotome morphogenesis.
decreased miRNA-27b regulates the activity of the CCL20/CCR6 axis by targeting Naa15, and promotes plaque stability in atherosclerosis
Title: miRNA-27b modulates endothelial cell angiogenesis by directly targeting Naa15 in atherogenesis.
tbdn-1 inhibits capillary-like formation in vitro and may serve to dampen vitreal blood vessel formation preceding the regression of the vitreal vasculature during development.
Title: Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro.
Tbdn-1 expression is important for retinal blood vessel homeostasis and for controlling retinal neovascularization in adults.
Title: Conditional knockdown of tubedown-1 in endothelial cells leads to neovascular retinopathy.
Loss of retinal endothelial Tbdn-1 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity.
Title: Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_15315-15316:1013436374:1 (e-PCR)
- UniSTS:267809

NARG1 (e-PCR)
- UniSTS:503367

BE199494 (e-PCR)
- UniSTS:207483

NoName (e-PCR)
- UniSTS:234672

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info
contributes_to ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NatA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatA complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 15, NatA auxiliary subunit

Names: N-terminal acetyltransferase 1; N-terminal aceyltransferase 1; NMDA receptor-regulated gene 1; NMDA receptor-regulated protein 1; protein tubedown-1; tubedown

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.