Nfat5 nuclear factor of activated T cells 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfat5provided by MGI
Official Full Name: nuclear factor of activated T cells 5provided by MGI
Primary source: MGI:MGI:1859333
See related: Ensembl:ENSMUSG00000003847 AllianceGenome:MGI:1859333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAG-8; CAG80; OREBP; nfatz; NFATL1; TonEBP; mKIAA0827; B130038B15Rik
Summary: Enables DNA binding activity. Acts upstream of or within positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; and regulation of calcineurin-NFAT signaling cascade. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human NFAT5 (nuclear factor of activated T cells 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 18.9), bladder adult (RPKM 16.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.93 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (108020072..108106149)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (107293435..107379517)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNHG14 Elevates NFAT5 Expression Through Sequestering miR-375-3p to Promote MPP + -Induced Neuronal Apoptosis, Inflammation, and Oxidative Stress in Parkinson's Disease.
Title: SNHG14 Elevates NFAT5 Expression Through Sequestering miR-375-3p to Promote MPP + -Induced Neuronal Apoptosis, Inflammation, and Oxidative Stress in Parkinson's Disease.
A comparative analysis of TonEBP conditional knockout mouse models reveals inter-dependency between compartments of the intervertebral disc.
Title: A comparative analysis of TonEBP conditional knockout mouse models reveals inter-dependency between compartments of the intervertebral disc.
Serum amyloid A expression in liver promotes synovial macrophage activation and chronic arthritis via NFAT5.
Title: Serum amyloid A expression in liver promotes synovial macrophage activation and chronic arthritis via NFAT5.
TonEBP: A Key Transcription Factor in Microglia Following Intracerebral Hemorrhage Induced-Neuroinflammation.
Title: TonEBP: A Key Transcription Factor in Microglia Following Intracerebral Hemorrhage Induced-Neuroinflammation.
Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice.
Title: Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice.
TonEBP Haploinsufficiency Attenuates Microglial Activation and Memory Deficits in Middle-Aged and Amyloid beta Oligomer-Treated Mice.
Title: TonEBP Haploinsufficiency Attenuates Microglial Activation and Memory Deficits in Middle-Aged and Amyloid β Oligomer-Treated Mice.
Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways.
Title: Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways.
circCELF1 Induces the Apoptosis and Autophagy of Astrocytes in Ischemic Stroke via Upregulating NFAT5.
Title: circCELF1 Induces the Apoptosis and Autophagy of Astrocytes in Ischemic Stroke via Upregulating NFAT5.
The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury.
Title: The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury.
The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression.
Title: The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224825

Nfat5 (e-PCR), detects polymorphism
- UniSTS:532283

RH135986 (e-PCR)
- UniSTS:209982

UniSTS:224902 (e-PCR)
- UniSTS:224902

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in R-loop processing	ISO Inferred from Sequence Orthology more info
involved_in R-loop processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of urine volume	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of renal water homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in response to water deprivation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor of activated T-cells 5

Names: T-cell transcription factor NFAT5; rel domain-containing transcription factor NFAT5; tonicity-responsive enhancer binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286260.1 → NP_001273189.1 nuclear factor of activated T-cells 5 isoform c

See identical proteins and their annotated locations for NP_001273189.1

Status: VALIDATED

Description

Transcript Variant: This variant (c) uses an alternate splice site and lacks a portion of the 3' coding region, compared to variant b. This results in a shorter protein (isoform c) with a distinct C-terminus, compared to variant b.

Source sequence(s)

AC158364, AK052632, AK134022, BE633760

Consensus CDS

CCDS72168.1

UniProtKB/Swiss-Prot

Q9WV30

UniProtKB/TrEMBL

Q3UZ77

Related

ENSMUSP00000075311.5, ENSMUST00000075922.11

Conserved Domains (2) summary

cd07882
Location:280 → 440

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:444 → 543

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_018823.2 → NP_061293.2 nuclear factor of activated T-cells 5 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (b) encodes the longest isoform (b).

Source sequence(s)

AC158364, AF200687, AF369980, AK045123, BE633760

Consensus CDS

CCDS22648.2

UniProtKB/TrEMBL

Q8VHJ6

Related

ENSMUSP00000127784.2, ENSMUST00000169453.8

Conserved Domains (2) summary

cd07882
Location:298 → 458

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:462 → 561

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_133957.3 → NP_598718.2 nuclear factor of activated T-cells 5 isoform a

See identical proteins and their annotated locations for NP_598718.2

Status: VALIDATED

Description

Transcript Variant: This variant (a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. This results in a protein (isoform a) with a shorter N-terminus, compared to isoform b.

Source sequence(s)

AC158364, AF200687, AF369980, AK045123, BE633760

Consensus CDS

CCDS40464.1

UniProtKB/TrEMBL

A0A1U6URG8, Q8VHJ6

Conserved Domains (3) summary

cd07882
Location:204 → 364

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:368 → 467

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1124 → 1365

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

108020072..108106149

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531192.4 → XP_006531255.1 nuclear factor of activated T-cells 5 isoform X2

See identical proteins and their annotated locations for XP_006531255.1

UniProtKB/Swiss-Prot

E9Q0P3, E9Q6U2, G5E8N9, Q91WY0, Q9JLA1, Q9WV30

UniProtKB/TrEMBL

Q8VHJ6

Related

ENSMUSP00000116094.2, ENSMUST00000125721.8

Conserved Domains (3) summary

cd07882
Location:280 → 440

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:444 → 543

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1200 → 1441

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_030243679.1 → XP_030099539.1 nuclear factor of activated T-cells 5 isoform X3

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (3) summary

cd07882
Location:280 → 440

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:444 → 543

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1199 → 1440

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_030243680.1 → XP_030099540.1 nuclear factor of activated T-cells 5 isoform X5

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (3) summary

cd07882
Location:233 → 393

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:397 → 496

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1153 → 1394

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_030243681.2 → XP_030099541.1 nuclear factor of activated T-cells 5 isoform X6

UniProtKB/TrEMBL

A0A1U6URG8, Q8VHJ6

Related

ENSMUSP00000076653.7, ENSMUST00000077440.13

Conserved Domains (3) summary

cd07882
Location:204 → 364

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:368 → 467

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1124 → 1365

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_006531191.4 → XP_006531254.1 nuclear factor of activated T-cells 5 isoform X1

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (3) summary

cd07882
Location:298 → 458

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:462 → 561

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1217 → 1458

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_006531193.4 → XP_006531256.1 nuclear factor of activated T-cells 5 isoform X4

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (3) summary

cd07882
Location:251 → 411

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:415 → 514

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1171 → 1412

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_036154180.1 → XP_036010073.1 nuclear factor of activated T-cells 5 isoform X7

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:204 → 364

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:368 → 467

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_036154184.1 → XP_036010077.1 nuclear factor of activated T-cells 5 isoform X11

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:56 → 216

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:220 → 319

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_006531194.3 → XP_006531257.1 nuclear factor of activated T-cells 5 isoform X8

See identical proteins and their annotated locations for XP_006531257.1

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:98 → 258

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:262 → 361

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_006531196.3 → XP_006531259.1 nuclear factor of activated T-cells 5 isoform X9

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:74 → 234

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:238 → 337

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_030243682.2 → XP_030099542.1 nuclear factor of activated T-cells 5 isoform X8

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:98 → 258

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:262 → 361

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_036154182.1 → XP_036010075.1 nuclear factor of activated T-cells 5 isoform X9

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:74 → 234

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:238 → 337

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_036154181.1 → XP_036010074.1 nuclear factor of activated T-cells 5 isoform X8

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:98 → 258

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:262 → 361

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_036154183.1 → XP_036010076.1 nuclear factor of activated T-cells 5 isoform X10

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:74 → 234

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:238 → 337

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_017312904.3 → XP_017168393.1 nuclear factor of activated T-cells 5 isoform X6

UniProtKB/TrEMBL

A0A1U6URG8, Q8VHJ6

Conserved Domains (3) summary

cd07882
Location:204 → 364

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:368 → 467

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

pfam09606
Location:1124 → 1365

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_017312905.3 → XP_017168394.1 nuclear factor of activated T-cells 5 isoform X8

UniProtKB/TrEMBL

Q8VHJ6

Conserved Domains (2) summary

cd07882
Location:98 → 258

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:262 → 361

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.