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    Pxylp1 2-phosphoxylose phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 235534, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pxylp1provided by MGI
    Official Full Name
    2-phosphoxylose phosphatase 1provided by MGI
    Primary source
    MGI:MGI:2442444
    See related
    Ensembl:ENSMUSG00000043587 AllianceGenome:MGI:2442444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acpl2; 9430094M07Rik; C130099A20Rik
    Summary
    Predicted to enable phosphatase activity. Predicted to be involved in chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in central nervous system; jaw; musculoskeletal system; and olfactory epithelium. Orthologous to human PXYLP1 (2-phosphoxylose phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 9.1), CNS E14 (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pxylp1 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.71 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96705396..96774732, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96823336..96892688, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C430002N11 gene Neighboring gene STARR-positive B cell enhancer ABC_E11752 Neighboring gene STARR-seq mESC enhancer starr_24980 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene peptidylprolyl isomerase A-like pseudogene Neighboring gene predicted gene, 51657

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Butts JC, et al. Dev Cell, 2024 Aug 19. PMID 39106860
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38214, DKFZp434B2119

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-phosphoxylose phosphatase 1
    Names
    acid phosphatase-like 2
    acid phosphatase-like protein 2
    NP_001276574.1
    NP_001276575.1
    NP_001276576.1
    NP_700469.1
    XP_006511201.1
    XP_006511202.1
    XP_017168835.1
    XP_030100200.1
    XP_030100201.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289645.1 → NP_001276574.1  2-phosphoxylose phosphatase 1

      See identical proteins and their annotated locations for NP_001276574.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC120869, AK036973
      Consensus CDS
      CCDS23418.1
      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Related
      ENSMUSP00000113210.2, ENSMUST00000120101.8
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. NM_001289646.1 → NP_001276575.1  2-phosphoxylose phosphatase 1

      See identical proteins and their annotated locations for NP_001276575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC120869, AK144699
      Consensus CDS
      CCDS23418.1
      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Related
      ENSMUSP00000113489.2, ENSMUST00000119141.8
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    3. NM_001289647.1 → NP_001276576.1  2-phosphoxylose phosphatase 1

      See identical proteins and their annotated locations for NP_001276576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC120869, AK082059
      Consensus CDS
      CCDS23418.1
      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Related
      ENSMUSP00000077571.2, ENSMUST00000078478.8
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    4. NM_153420.3 → NP_700469.1  2-phosphoxylose phosphatase 1

      See identical proteins and their annotated locations for NP_700469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC120869
      Consensus CDS
      CCDS23418.1
      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Related
      ENSMUSP00000108574.3, ENSMUST00000112951.9
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96705396..96774732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511138.4 → XP_006511201.1  2-phosphoxylose phosphatase 1 isoform X1

      See identical proteins and their annotated locations for XP_006511201.1

      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. XM_030244340.2 → XP_030100200.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    3. XM_030244341.2 → XP_030100201.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    4. XM_017313346.2 → XP_017168835.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHA9, Q8BZ12
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    5. XM_006511139.3 → XP_006511202.1  2-phosphoxylose phosphatase 1 isoform X2

      Conserved Domains (1) summary
      cl11399
      Location:71 → 408
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHA9.1 GenPept UniProtKB/Swiss-Prot:Q8BHA9

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