Mir34c microRNA 34c [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir34cprovided by MGI
Official Full Name: microRNA 34cprovided by MGI
Primary source: MGI:MGI:3619365
See related: Ensembl:ENSMUSG00000065587 miRBase:MI0000403; AllianceGenome:MGI:3619365
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn34c; mir-34c; mmu-mir-34c
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 9 A5.3; 9 27.83 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (51014334..51014410, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (51103034..51103110, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential Impairment Mechanism of Sperm Production via Induction of miR-34c-Activated Apoptosis and Spermatogenesis Pathway in Diet-Induced Obesity and Resistant Mice and GC-1 Spg Cells.
Title: Differential Impairment Mechanism of Sperm Production via Induction of miR-34c-Activated Apoptosis and Spermatogenesis Pathway in Diet-Induced Obesity and Resistant Mice and GC-1 Spg Cells.
Inhibition of microRNA-34c reduces detrusor ROCK2 expression and urinary bladder inflammation in experimental cystitis.
Title: Inhibition of microRNA-34c reduces detrusor ROCK2 expression and urinary bladder inflammation in experimental cystitis.
The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis.
Title: The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis.
Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice.
Title: Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice.
Downregulation of miR-34c-5p alleviates chronic intermittent hypoxia-induced myocardial damage by targeting sirtuin 1.
Title: Downregulation of miR-34c-5p alleviates chronic intermittent hypoxia-induced myocardial damage by targeting sirtuin 1.
Protective Role of miR-34c in Hypoxia by Activating Autophagy through BCL2 Repression.
Title: Protective Role of miR-34c in Hypoxia by Activating Autophagy through BCL2 Repression.
Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
Title: Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
Effects of miR-34c-5p on Sodium, Potassium, and Calcium Channel Currents in C2C12 Myotubes.
Title: Effects of miR-34c-5p on Sodium, Potassium, and Calcium Channel Currents in C2C12 Myotubes.
Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease.
Title: Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease.
miR-34b/c regulates doxorubicin-induced myocardial cell injury through ITCH.
Title: miR-34b/c regulates doxorubicin-induced myocardial cell injury through ITCH.

Submit: New GeneRIF Correction See all GeneRIFs (46)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to forskolin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within embryonic brain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ossification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.