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    Dbh dopamine beta hydroxylase [ Mus musculus (house mouse) ]

    Gene ID: 13166, updated on 17-Dec-2024

    Summary

    Official Symbol
    Dbhprovided by MGI
    Official Full Name
    dopamine beta hydroxylaseprovided by MGI
    Primary source
    MGI:MGI:94864
    See related
    Ensembl:ENSMUSG00000000889 AllianceGenome:MGI:94864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; homoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward adrenal adult (RPKM 151.1) See more
    Orthologs
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    Genomic context

    See Dbh in Genome Data Viewer
    Location:
    2 A3; 2 19.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27055519..27073216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27165507..27183204)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26977601-26977932 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26981648-26981757 Neighboring gene family with sequence similarity 163, member B Neighboring gene dopamine beta hydroxylase, opposite strand Neighboring gene sarcosine dehydrogenase Neighboring gene vav 2 oncogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene Vav2R3 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R5 erythroid cis-regulatory module

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-ascorbic acid binding  
    enables copper ion binding  
    enables copper ion binding  
    enables copper ion binding  
    enables dopamine beta-monooxygenase activity  
    enables dopamine beta-monooxygenase activity  
    enables dopamine beta-monooxygenase activity  
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    acts_upstream_of_or_within associative learning PubMed 
    acts_upstream_of_or_within behavioral response to ethanol PubMed 
    acts_upstream_of_or_within blood vessel remodeling PubMed 
    acts_upstream_of_or_within cytokine production PubMed 
    involved_in dopamine catabolic process  
    acts_upstream_of_or_within dopamine catabolic process PubMed 
    involved_in dopamine catabolic process PubMed 
    involved_in dopamine catabolic process  
    involved_in dopamine catabolic process  
    acts_upstream_of_or_within fear response PubMed 
    acts_upstream_of_or_within glucose homeostasis PubMed 
    acts_upstream_of_or_within homoiothermy PubMed 
    acts_upstream_of_or_within leukocyte mediated immunity PubMed 
    acts_upstream_of_or_within leukocyte migration PubMed 
    acts_upstream_of_or_within locomotory behavior PubMed 
    involved_in locomotory behavior PubMed 
    acts_upstream_of_or_within maternal behavior PubMed 
    acts_upstream_of_or_within memory PubMed 
    involved_in norepinephrine biosynthetic process  
    involved_in norepinephrine biosynthetic process  
    acts_upstream_of_or_within norepinephrine biosynthetic process PubMed 
    involved_in norepinephrine biosynthetic process PubMed 
    involved_in norepinephrine biosynthetic process  
    involved_in norepinephrine biosynthetic process  
    involved_in octopamine biosynthetic process  
    involved_in octopamine metabolic process  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    acts_upstream_of_or_within positive regulation of vasoconstriction PubMed 
    acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within regulation of vascular associated smooth muscle cell proliferation PubMed 
    acts_upstream_of_or_within regulation of vascular endothelial cell proliferation PubMed 
    acts_upstream_of_or_within response to amphetamine PubMed 
    acts_upstream_of_or_within response to pain PubMed 
    acts_upstream_of vasoconstriction PubMed 
    acts_upstream_of_or_within visual learning PubMed 
    Items 1 - 25 of 35
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in apical part of cell  
    located_in axon  
    located_in centriolar satellite  
    located_in centriolar satellite  
    located_in chromaffin granule lumen  
    located_in chromaffin granule membrane  
    located_in dendrite  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    located_in neuronal cell body  
    located_in secretory granule lumen PubMed 
    located_in secretory granule lumen  
    is_active_in secretory granule membrane  
    located_in secretory granule membrane PubMed 
    located_in secretory granule membrane  
    located_in terminal bouton  
    located_in transport vesicle membrane  
    located_in varicosity  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    dopamine beta-hydroxylase
    Names
    dopamine beta-monooxygenase
    NP_620392.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138942.3NP_620392.2  dopamine beta-hydroxylase

      See identical proteins and their annotated locations for NP_620392.2

      Status: VALIDATED

      Source sequence(s)
      AK132245, BB109310
      Consensus CDS
      CCDS38088.1
      UniProtKB/Swiss-Prot
      Q3V1U4, Q64237
      Related
      ENSMUSP00000000910.7, ENSMUST00000000910.7
      Conserved Domains (3) summary
      pfam01082
      Location:217344
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:61176
      DOMON; DOMON domain
      pfam03712
      Location:365520
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      27055519..27073216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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