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    Arhgef37 Rho guanine nucleotide exchange factor 37 [ Mus musculus (house mouse) ]

    Gene ID: 328967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef37provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 37provided by MGI
    Primary source
    MGI:MGI:3045339
    See related
    Ensembl:ENSMUSG00000045094 AllianceGenome:MGI:3045339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933429F08Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Orthologous to human ARHGEF37 (Rho guanine nucleotide exchange factor 37). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 2.5), genital fat pad adult (RPKM 2.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef37 in Genome Data Viewer
    Location:
    18 E1; 18 34.62 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61624728..61669994, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61491657..61536928, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene brown adipose tissue enriched long noncoding RNA 10 Neighboring gene predicted gene, 46637 Neighboring gene STARR-seq mESC enhancer starr_44745 Neighboring gene STARR-seq mESC enhancer starr_44746 Neighboring gene STARR-positive B cell enhancer ABC_E9979 Neighboring gene STARR-seq mESC enhancer starr_44748 Neighboring gene casein kinase 1, alpha 1 Neighboring gene VISTA enhancer mm36 Neighboring gene predicted gene, 41747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 37
    Names
    Rho guanine nucleotide exchange factor (GEF) 37
    probable guanine nucleotide exchange factor FLJ41603 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177828.4 → NP_808496.2  rho guanine nucleotide exchange factor 37

      See identical proteins and their annotated locations for NP_808496.2

      Status: VALIDATED

      Source sequence(s)
      AC153155, AK030242, AK177275, CJ045695, CJ131942
      Consensus CDS
      CCDS50302.1
      UniProtKB/Swiss-Prot
      A1IGU4, Q8C0M3
      UniProtKB/TrEMBL
      E9Q5R6
      Related
      ENSMUSP00000130560.2, ENSMUST00000171629.3
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:607 → 663
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 211
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61624728..61669994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526028.5 → XP_006526091.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_006526091.1

      UniProtKB/Swiss-Prot
      A1IGU4, Q8C0M3
      UniProtKB/TrEMBL
      E9Q5R6
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:607 → 663
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 211
      RhoGEF; RhoGEF domain

    2. XM_006526027.5 → XP_006526090.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_006526090.1

      UniProtKB/Swiss-Prot
      A1IGU4, Q8C0M3
      UniProtKB/TrEMBL
      E9Q5R6
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:607 → 663
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 211
      RhoGEF; RhoGEF domain

    3. XM_036161182.1 → XP_036017075.1  rho guanine nucleotide exchange factor 37 isoform X2

      Related
      ENSMUSP00000157463.2, ENSMUST00000236608.2
      Conserved Domains (3) summary
      cd07589
      Location:50 → 238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296 → 349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:393 → 449
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

    4. XM_030250512.2 → XP_030106372.1  rho guanine nucleotide exchange factor 37 isoform X2

      Conserved Domains (3) summary
      cd07589
      Location:50 → 238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296 → 349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:393 → 449
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

    5. XM_011246947.4 → XP_011245249.1  rho guanine nucleotide exchange factor 37 isoform X2

      See identical proteins and their annotated locations for XP_011245249.1

      Conserved Domains (3) summary
      cd07589
      Location:50 → 238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296 → 349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:393 → 449
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

    6. XM_011246946.4 → XP_011245248.1  rho guanine nucleotide exchange factor 37 isoform X2

      See identical proteins and their annotated locations for XP_011245248.1

      Conserved Domains (3) summary
      cd07589
      Location:50 → 238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296 → 349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:393 → 449
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1IGU4.1 GenPept UniProtKB/Swiss-Prot:A1IGU4

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