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    Rnf14 ring finger protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 56736, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf14provided by MGI
    Official Full Name
    ring finger protein 14provided by MGI
    Primary source
    MGI:MGI:1929668
    See related
    Ensembl:ENSMUSG00000060450 AllianceGenome:MGI:1929668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Triad2; D7Bwg0165e; D18Ertd188e; 2310075C09Rik; 2610005D23Rik
    Summary
    Predicted to enable nuclear androgen receptor binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein K6-linked ubiquitination; protein-RNA covalent cross-linking repair; and regulation of signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; genitourinary system; sensory organ; and trigeminal nerve. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 51.1), cortex adult (RPKM 38.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rnf14 in Genome Data Viewer
    Location:
    18 B3; 18 20.2 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38410513..38450905)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38277460..38317852)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700086O06 gene Neighboring gene 60S ribosomal protein L17-like Neighboring gene STARR-positive B cell enhancer ABC_E7580 Neighboring gene STARR-seq mESC enhancer starr_44353 Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene protocadherin 12 Neighboring gene STARR-seq mESC enhancer starr_44354 Neighboring gene predicted gene, 23205 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10986 Neighboring gene predicted gene, 41702 Neighboring gene STARR-seq mESC enhancer starr_44355 Neighboring gene predicted gene, 52329

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear androgen receptor binding  
    enables nuclear androgen receptor binding  
    enables ubiquitin conjugating enzyme binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-like protein transferase activity  
    enables ubiquitin-like protein transferase activity PubMed 
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in protein K6-linked ubiquitination  
    involved_in protein K6-linked ubiquitination  
    involved_in protein-RNA covalent cross-linking repair  
    involved_in protein-RNA covalent cross-linking repair  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of androgen receptor signaling pathway  
    involved_in regulation of androgen receptor signaling pathway  
    involved_in regulation of canonical Wnt signaling pathway  
    involved_in regulation of canonical Wnt signaling pathway  
    involved_in rescue of stalled ribosome  
    involved_in rescue of stalled ribosome  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosolic ribosome  
    is_active_in cytosolic ribosome  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus PubMed 
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF14
    Names
    TRIAD2 type I
    androgen receptor-associated protein 54
    protein Triad2
    NP_001158093.1
    NP_001158094.1
    NP_001348193.1
    NP_001348194.1
    NP_001348195.1
    NP_001348196.1
    NP_001348197.1
    NP_001348198.1
    NP_064396.2
    XP_006526189.1
    XP_006526190.1
    XP_006526191.1
    XP_017173445.1
    XP_017173446.1
    XP_030106408.1
    XP_030106410.1
    XP_030106411.1
    XP_030106412.1
    XP_030106413.1
    XP_030106414.1
    XP_036017113.1
    XP_036017115.1
    XP_036017116.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164621.1NP_001158093.1  E3 ubiquitin-protein ligase RNF14 isoform a

      See identical proteins and their annotated locations for NP_001158093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      BC049079, BC094250
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Related
      ENSMUSP00000126205.2, ENSMUST00000171461.3
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    2. NM_001164622.1NP_001158094.1  E3 ubiquitin-protein ligase RNF14 isoform b

      See identical proteins and their annotated locations for NP_001158094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK038986, BC094250, CA315275
      Consensus CDS
      CCDS50261.1
      UniProtKB/TrEMBL
      G3XA54
      Related
      ENSMUSP00000133070.2, ENSMUST00000170811.8
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    3. NM_001361264.1NP_001348193.1  E3 ubiquitin-protein ligase RNF14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      AC152450
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    4. NM_001361265.1NP_001348194.1  E3 ubiquitin-protein ligase RNF14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      AC152450
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    5. NM_001361266.1NP_001348195.1  E3 ubiquitin-protein ligase RNF14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      AC152450
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    6. NM_001361267.1NP_001348196.1  E3 ubiquitin-protein ligase RNF14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      AC152450
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Related
      ENSMUSP00000157833.2, ENSMUST00000236116.2
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    7. NM_001361268.1NP_001348197.1  E3 ubiquitin-protein ligase RNF14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      AC152450
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    8. NM_001361269.1NP_001348198.1  E3 ubiquitin-protein ligase RNF14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      AC152450
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    9. NM_020012.2NP_064396.2  E3 ubiquitin-protein ligase RNF14 isoform a

      See identical proteins and their annotated locations for NP_064396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
      Source sequence(s)
      BC054841, BC094250, CA315275
      Consensus CDS
      CCDS29200.1
      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Related
      ENSMUSP00000072212.6, ENSMUST00000072376.13
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      38410513..38450905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317957.1XP_017173446.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    2. XM_017317956.2XP_017173445.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    3. XM_036161220.1XP_036017113.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    4. XM_006526126.2XP_006526189.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      See identical proteins and their annotated locations for XP_006526189.1

      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    5. XM_036161222.1XP_036017115.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    6. XM_030250550.1XP_030106410.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    7. XM_030250551.1XP_030106411.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    8. XM_006526128.2XP_006526191.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      See identical proteins and their annotated locations for XP_006526191.1

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    9. XM_030250552.1XP_030106412.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    10. XM_030250553.1XP_030106413.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    11. XM_006526127.3XP_006526190.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      See identical proteins and their annotated locations for XP_006526190.1

      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
    12. XM_030250554.1XP_030106414.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    13. XM_036161223.1XP_036017116.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      G3XA54
      Conserved Domains (3) summary
      smart00647
      Location:164225
      IBR; In Between Ring fingers
      cd16628
      Location:93146
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:252308
      IBR; IBR domain, a half RING-finger domain
    14. XM_030250548.1XP_030106408.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
      Conserved Domains (4) summary
      smart00647
      Location:290351
      IBR; In Between Ring fingers
      cd16628
      Location:219272
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:378434
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
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