Tnfrsf17 tumor necrosis factor receptor superfamily, member 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf17provided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 17provided by MGI
Primary source: MGI:MGI:1343050
See related: Ensembl:ENSMUSG00000022496 AllianceGenome:MGI:1343050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BCM; BCMA; Tnfrsf13; Tnfrsf13a
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within lymphocyte homeostasis. Predicted to be located in membrane. Is expressed in several structures, including hemolymphoid system gland; hippocampus; male reproductive gland or organ; superior cervical ganglion; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and multiple myeloma. Orthologous to human TNFRSF17 (TNF receptor superfamily member 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 2.7), duodenum adult (RPKM 1.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 6.42 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (11131131..11137938)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (11313232..11320074)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA
Title: Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.
Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice.
Title: Differential Development of Systemic Lupus Erythematosus in NZM 2328 Mice Deficient in Discrete Pairs of BAFF Receptors.
we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils.
Title: Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.
Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR.
Title: Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE.
Title: Development of systemic lupus erythematosus in NZM 2328 mice in the absence of any single BAFF receptor.
Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity.
Title: B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.
Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells.
Title: B-lymphocyte-induced maturation protein1 up-regulates the expression of B-cell maturation antigen in mouse plasma cells.
The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity.
Title: [Promoter activity of B-cell maturation antigen gene in mice].
Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.
Title: The role of the BAFF/APRIL system on T cell function.
Review. APRIL interactions with BCMA likely govern memory B cell populations.
Title: BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymphocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 17

Names: B-cell maturation protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011608.1 → NP_035738.1 tumor necrosis factor receptor superfamily member 17

See identical proteins and their annotated locations for NP_035738.1

Status: PROVISIONAL

Source sequence(s)

AF061505

Consensus CDS

CCDS27962.1

UniProtKB/Swiss-Prot

O88472

Related

ENSMUSP00000023140.6, ENSMUST00000023140.6

Conserved Domains (1) summary

cd13414
Location:1 → 165

TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

11131131..11137938

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521990.4 → XP_006522053.1 tumor necrosis factor receptor superfamily member 17 isoform X2

Conserved Domains (2) summary

cd00185
Location:1 → 18

TNFRSF; CRD1 [structural motif]

cl22855
Location:1 → 112

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_006521989.5 → XP_006522052.1 tumor necrosis factor receptor superfamily member 17 isoform X1

Conserved Domains (1) summary

cd13414
Location:1 → 161

TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A