Ptchd3 patched domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptchd3provided by MGI
Official Full Name: patched domain containing 3provided by MGI
Primary source: MGI:MGI:1921925
See related: Ensembl:ENSMUSG00000039198 AllianceGenome:MGI:1921925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RNDEu-3; 4930451E13Rik; 4933440L20Rik
Summary: Located in sperm midpiece. Orthologous to human PTCHD3 (patched domain containing 3 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 19.1) See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 87.9 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (121721050..121734259)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121830218..121843438)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse Ptchd3 is a non-essential gene.
Title: Mouse Ptchd3 is a non-essential gene.
Results indicate that Ptchd3 is a novel male germ cell-specific gene and may be involved in the Hh signaling to regulate sperm development and/or sperm function.
Title: Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: patched domain-containing protein 3

Names: RND-type protein RNDEu-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029049.2 → NP_083325.1 patched domain-containing protein 3

See identical proteins and their annotated locations for NP_083325.1

Status: VALIDATED

Source sequence(s)

AL663041

Consensus CDS

CCDS49014.1

UniProtKB/Swiss-Prot

A2AC39, Q0EEE2, Q9CUM1, Q9D3R2

Related

ENSMUSP00000035709.7, ENSMUST00000036690.7

Conserved Domains (2) summary

pfam02460
Location:127 → 906

Patched; Patched family

cl21543
Location:363 → 503

MMPL; MMPL family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

121721050..121734259

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534383.4 → XP_006534446.1 patched domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

B7ZN87

Conserved Domains (1) summary

cl25655
Location:127 → 409

Patched; Patched family