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    Mnt max binding protein [ Mus musculus (house mouse) ]

    Gene ID: 17428, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mntprovided by MGI
    Official Full Name
    max binding proteinprovided by MGI
    Primary source
    MGI:MGI:109150
    See related
    Ensembl:ENSMUSG00000000282 AllianceGenome:MGI:109150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rox; bHLHd3
    Summary
    Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Acts upstream of or within several processes, including cellular senescence; negative regulation of apoptotic signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and retina nuclear layer. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.8), adrenal adult (RPKM 10.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mnt in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74721651..74736551)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74830806..74845725)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40198 Neighboring gene STARR-seq mESC enhancer starr_29970 Neighboring gene STARR-seq mESC enhancer starr_29971 Neighboring gene STARR-positive B cell enhancer ABC_E3000 Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene predicted gene, 57584 Neighboring gene STARR-positive B cell enhancer ABC_E8879 Neighboring gene STARR-positive B cell enhancer ABC_E11484 Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926 Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene TSR1 20S rRNA accumulation Neighboring gene serine racemase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    max-binding protein MNT
    Names
    myc antagonist MNT

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010813.3NP_034943.3  max-binding protein MNT

      See identical proteins and their annotated locations for NP_034943.3

      Status: VALIDATED

      Source sequence(s)
      AW491765, BC054534, CA327080
      Consensus CDS
      CCDS25037.1
      UniProtKB/Swiss-Prot
      O08789, P97349, Q6GTJ3
      UniProtKB/TrEMBL
      Q3UGG9
      Related
      ENSMUSP00000000291.3, ENSMUST00000000291.9
      Conserved Domains (1) summary
      cd11402
      Location:222298
      bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74721651..74736551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532402.5XP_006532465.1  max-binding protein MNT isoform X1

      UniProtKB/TrEMBL
      Q3UGG9
      Conserved Domains (2) summary
      pfam10944
      Location:267325
      DUF2630; Protein of unknown function (DUF2630)
      cd11402
      Location:221284
      bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins
    2. XM_006532403.4XP_006532466.1  max-binding protein MNT isoform X2

    3. XM_036156377.1XP_036012270.1  max-binding protein MNT isoform X2

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