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    Rab1a RAB1A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81754, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rab1aprovided by RGD
    Official Full Name
    RAB1A, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:619736
    See related
    EnsemblRapid:ENSRNOG00000004992 AllianceGenome:RGD:619736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rab1; Rab1r; Ac2-048
    Summary
    Enables GTP binding activity. Involved in endocytosis and vesicle transport along microtubule. Acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport. Located in several cellular components, including Golgi membrane; early endosome; and neuronal cell body. Is active in presynapse. Orthologous to human RAB1A (RAB1A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 1111.0), Liver (RPKM 914.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rab1a in Genome Data Viewer
    Location:
    14q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (98623582..98648766)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (94422219..94448799)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104475082..104500176)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27, pseudogene 8 Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene centrosomal protein 68 Neighboring gene solute carrier family 1 member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading  
    involved_in Golgi organization  
    involved_in Golgi organization  
    involved_in Rab protein signal transduction PubMed 
    involved_in autophagosome assembly  
    involved_in autophagosome assembly  
    involved_in autophagosome assembly  
    involved_in autophagy  
    involved_in autophagy  
    involved_in cell migration  
    involved_in cell migration  
    NOT involved_in cilium assembly  
    involved_in defense response to bacterium  
    involved_in defense response to bacterium  
    involved_in endocytosis PubMed 
    involved_in endocytosis  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    NOT involved_in establishment of endothelial intestinal barrier  
    involved_in growth hormone secretion  
    involved_in growth hormone secretion  
    involved_in intracellular protein transport  
    involved_in melanosome transport  
    involved_in positive regulation of glycoprotein metabolic process  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in vesicle transport along microtubule PubMed 
    involved_in vesicle transport along microtubule  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane PubMed 
    located_in cytosol  
    located_in early endosome PubMed 
    is_active_in endomembrane system  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane PubMed 
    located_in exocytic vesicle  
    located_in melanosome  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    located_in presynapse PubMed 
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-1A
    Names
    RAB1, member RAS oncogene family
    NP_112352.2
    XP_038948414.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031090.3NP_112352.2  ras-related protein Rab-1A

      See identical proteins and their annotated locations for NP_112352.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P10536, Q6NYB7
      UniProtKB/TrEMBL
      A6JQ16
      Related
      ENSRNOP00000073493.3, ENSRNOT00000084481.3
      Conserved Domains (1) summary
      cd01869
      Location:10175
      Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      98623582..98648766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092486.2XP_038948414.1  ras-related protein Rab-1A isoform X1

      UniProtKB/TrEMBL
      A6JQ17
      Related
      ENSRNOP00000107962.1, ENSRNOT00000167788.1
      Conserved Domains (1) summary
      cl38936
      Location:10143
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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