Mmp24 matrix metallopeptidase 24 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mmp24provided by RGD
Official Full Name: matrix metallopeptidase 24provided by RGD
Primary source: RGD:620202
See related: EnsemblRapid:ENSRNOG00000047028 AllianceGenome:RGD:620202
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MT5MMP; MTMMP5; Mt5-mmp
Summary: Predicted to enable cadherin binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; collagen catabolic process; and detection of temperature stimulus involved in sensory perception of pain. Predicted to be located in trans-Golgi network membrane. Predicted to be active in extracellular space and plasma membrane. Orthologous to human MMP24 (matrix metallopeptidase 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 159.5), Kidney (RPKM 40.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164739226..164783696)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144279096..144323572)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151307309..151355401)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Time- and injury-dependent expression of MT5-MMP, ADAM-10, and N-cadherin are confirmed during reactive synaptogenesis.
Title: MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury.
These results suggest that ABP directs MT5-MMP proteolytic activity to growth cones and synaptic sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolysis of cadherins or other ECM or cell adhesion molecules.
Title: Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherins.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135475 (e-PCR)
- UniSTS:158743

RH135119 (e-PCR)
- UniSTS:218396

D3Got110 (e-PCR)
- UniSTS:114063

RH128047 (e-PCR)
- UniSTS:211355

REN57077 (e-PCR)
- UniSTS:381877

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activity	TAS Traceable Author Statement more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by cadherin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in neuronal stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: matrix metalloproteinase-24

Names: MMP-24; MT-MMP 5; matrix metalloproteinase 24 (membrane-inserted); membrane-type matrix metalloproteinase 5; membrane-type-5 matrix metalloproteinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031757.1 → NP_113945.1 matrix metalloproteinase-24 precursor

See identical proteins and their annotated locations for NP_113945.1

Status: PROVISIONAL

Source sequence(s)

AB023659

UniProtKB/Swiss-Prot

Q99PW6

UniProtKB/TrEMBL

A0A0G2KA10

Related

ENSRNOP00000075211.2, ENSRNOT00000092194.3

Conserved Domains (5) summary

cd00094
Location:350 → 542

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:135 → 300

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:135 → 300

Peptidase_M10; Matrixin

pfam01471
Location:55 → 107

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:548 → 618

DUF3377; Domain of unknown function (DUF3377)