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    HDAC4 histone deacetylase 4 [ Homo sapiens (human) ]

    Gene ID: 9759, updated on 27-Dec-2024

    Summary

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    Official Symbol
    HDAC4provided by HGNC
    Official Full Name
    histone deacetylase 4provided by HGNC
    Primary source
    HGNC:HGNC:14063
    See related
    Ensembl:ENSG00000068024 MIM:605314; AllianceGenome:HGNC:14063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; NEDCHF; NEDCHID
    Summary
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 1.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HDAC4 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (239048168..239401649, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (239539541..239892233, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (239969864..240323343, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239757217-239757726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239757727-239758237 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57450 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57458 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:239764522-239764712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239765771-239766270 Neighboring gene Sharpr-MPRA regulatory region 8511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239773413-239774030 Neighboring gene NANOG hESC enhancer GRCh37_chr2:239781475-239781979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239798834-239799355 Neighboring gene twist family bHLH transcription factor 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57501 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239864003-239864503 Neighboring gene long intergenic non-protein coding RNA 1940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239906676-239907658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239907659-239908639 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239936997-239937826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:239957575-239958194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239989039-239989540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239989541-239990040 Neighboring gene microRNA 4440 Neighboring gene uncharacterized LOC124908009 Neighboring gene microRNA 4441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111156-240111673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111674-240112190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240112520-240113118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240117946-240118446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240123022-240123588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240134871-240135376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136104-240136802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136803-240137501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240146814-240147708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240152211-240152711 Neighboring gene uncharacterized LOC85009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240153455-240153994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240165567-240166264 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:240168807-240170006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240174119-240174620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240183749-240184248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240185799-240186466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240194739-240195516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17386 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:240197413-240197621 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240212885-240213414 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240213415-240213946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12499 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:240217222-240217838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240217839-240218454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240229260-240229906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240232601-240233101 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:240274162-240274355 Neighboring gene microRNA 4269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240287637-240288172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240287100-240287636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240307588-240308438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12502 Neighboring gene microRNA 2467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240328963-240329914 Neighboring gene HDAC4 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240397877-240398834 Neighboring gene uncharacterized LOC124908011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240423087-240423588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240423589-240424088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240427462-240428150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240441589-240442260 Neighboring gene uncharacterized LOC124908012

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival. Wang Z, et al. Ann Clin Lab Sci, 2019 Mar. PMID 31028063
    2. Hepatitis C virus core protein enhances hepatocellular carcinoma cells to be susceptible to oncolytic vesicular stomatitis virus through down-regulation of HDAC4. Moon J, et al. Biochem Biophys Res Commun, 2016 Jun 3. PMID 27150631
    3. Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma. Zeng LS, et al. Aging (Albany NY), 2016 Jun. PMID 27295551, Free PMC Article
    4. Investigation of differential HDAC4 methylation patterns in eating disorders. Subramanian S, et al. Psychiatr Genet, 2018 Feb. PMID 29256967, Free PMC Article
    5. HDAC4 in ischemic stroke: mechanisms and therapeutic potential. Kong Q, et al. Clin Epigenetics, 2018 Sep 12. PMID 30208931, Free PMC Article

    See all (357) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-kappaB signaling pathway.
      Title: NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathway.
    2. Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced Alveolar Epithelial Cell Injury.
      Title: Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced Alveolar Epithelial Cell Injury.
    3. HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair.
      Title: HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair.
    4. Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.
      Title: Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.
    5. Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
      Title: Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
    6. ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.
      Title: ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.
    7. HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis.
      Title: HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis.
    8. Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation.
      Title: Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation.
    9. Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4.
      Title: Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4.
    10. LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.
      Title: LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.
    Submit: New GeneRIF Correction See all GeneRIFs (180)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Chromosome 2q37 deletion syndrome
    MedGen: C2931817 OMIM: 600430 GeneReviews: Not available
    		Compare labs
    Neurodevelopmental disorder with central hypotonia and dysmorphic facies
    MedGen: C5676944 OMIM: 619797 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2024-07-16)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2024-07-16)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog
    Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    reverse transcriptase gag-pol Amino acid starvation-dependent HDAC4 downregulation leads to HIV-1 transcriptional activation and RT activity production in T-lymphocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0288

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H3K14 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein lysine deacetylase activity TAS
    Traceable Author Statement
    more info
    		  
    contributes_to transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in B cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cardiac muscle hypertrophy in response to stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by competitive promoter binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidyl-lysine deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to denervation involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to interleukin-1 IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone deacetylase 4
    Names
    histone deacetylase A
    NP_001365343.1
    NP_001365344.1
    NP_001365345.1
    NP_001365346.1
    NP_006028.2
    XP_006712940.1
    XP_006712943.1
    XP_011510519.1
    XP_011510520.1
    XP_011510521.1
    XP_011510522.1
    XP_011510524.1
    XP_011510525.1
    XP_011510526.1
    XP_011510527.1
    XP_011510528.1
    XP_011510529.1
    XP_016860883.1
    XP_024309025.1
    XP_047302432.1
    XP_047302433.1
    XP_047302434.1
    XP_047302435.1
    XP_047302436.1
    XP_047302437.1
    XP_047302438.1
    XP_047302439.1
    XP_047302440.1
    XP_047302441.1
    XP_047302442.1
    XP_047302443.1
    XP_047302444.1
    XP_047302445.1
    XP_047302446.1
    XP_047302447.1
    XP_047302448.1
    XP_047302449.1
    XP_047302450.1
    XP_047302451.1
    XP_047302452.1
    XP_047302453.1
    XP_047302454.1
    XP_054200697.1
    XP_054200698.1
    XP_054200699.1
    XP_054200700.1
    XP_054200701.1
    XP_054200702.1
    XP_054200703.1
    XP_054200704.1
    XP_054200705.1
    XP_054200706.1
    XP_054200707.1
    XP_054200708.1
    XP_054200709.1
    XP_054200710.1
    XP_054200711.1
    XP_054200712.1
    XP_054200713.1
    XP_054200714.1
    XP_054200715.1
    XP_054200716.1
    XP_054200717.1
    XP_054200718.1
    XP_054200719.1
    XP_054200720.1
    XP_054200721.1
    XP_054200722.1
    XP_054200723.1
    XP_054200724.1
    XP_054200725.1
    XP_054200726.1
    XP_054200727.1
    XP_054200728.1
    XP_054200729.1
    XP_054200730.1
    XP_054200731.1
    XP_054200732.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009235.2 RefSeqGene

      Range
      5629..358481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001378414.1 → NP_001365343.1  histone deacetylase 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC017028, AC062017
      Consensus CDS
      CCDS92981.1
      UniProtKB/TrEMBL
      A0A7I2SVS4, Q53SM2
      Related
      ENSP00000440481.3, ENST00000543185.6
      Conserved Domains (2) summary
      cd10162
      Location:91 → 152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:654 → 1062
      HDAC4; Histone deacetylase 4

    2. NM_001378415.1 → NP_001365344.1  histone deacetylase 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC017028, AC062017
      Consensus CDS
      CCDS92981.1
      UniProtKB/TrEMBL
      A0A7I2SVS4, Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:91 → 152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:654 → 1062
      HDAC4; Histone deacetylase 4

    3. NM_001378416.1 → NP_001365345.1  histone deacetylase 4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC017028, AC062017
      Consensus CDS
      CCDS2529.1
      UniProtKB/Swiss-Prot
      E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:91 → 152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:649 → 1057
      HDAC4; Histone deacetylase 4

    4. NM_001378417.1 → NP_001365346.1  histone deacetylase 4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC017028, AC062017
      Consensus CDS
      CCDS2529.1
      UniProtKB/Swiss-Prot
      E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:91 → 152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:649 → 1057
      HDAC4; Histone deacetylase 4

    5. NM_006037.4 → NP_006028.2  histone deacetylase 4 isoform 2

      See identical proteins and their annotated locations for NP_006028.2

      Status: REVIEWED

      Source sequence(s)
      AC017028, AC062017
      Consensus CDS
      CCDS2529.1
      UniProtKB/Swiss-Prot
      E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
      UniProtKB/TrEMBL
      Q53SM2
      Related
      ENSP00000264606.3, ENST00000345617.7
      Conserved Domains (2) summary
      cd10162
      Location:91 → 152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:649 → 1057
      HDAC4; Histone deacetylase 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      239048168..239401649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446489.1 → XP_047302445.1  histone deacetylase 4 isoform X20

      UniProtKB/TrEMBL
      Q53SM2

    2. XM_047446486.1 → XP_047302442.1  histone deacetylase 4 isoform X17

      UniProtKB/TrEMBL
      Q53SM2

    3. XM_047446483.1 → XP_047302439.1  histone deacetylase 4 isoform X14

      UniProtKB/TrEMBL
      Q53SM2

    4. XM_047446498.1 → XP_047302454.1  histone deacetylase 4 isoform X29

      UniProtKB/TrEMBL
      Q53SM2

    5. XM_047446491.1 → XP_047302447.1  histone deacetylase 4 isoform X21

      UniProtKB/TrEMBL
      Q53SM2

    6. XM_047446490.1 → XP_047302446.1  histone deacetylase 4 isoform X20

      UniProtKB/TrEMBL
      Q53SM2

    7. XM_011512226.3 → XP_011510528.1  histone deacetylase 4 isoform X17

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:67 → 128
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:630 → 1038
      HDAC4; Histone deacetylase 4

    8. XM_047446496.1 → XP_047302452.1  histone deacetylase 4 isoform X27

      UniProtKB/TrEMBL
      Q53SM2

    9. XM_047446493.1 → XP_047302449.1  histone deacetylase 4 isoform X24

      UniProtKB/TrEMBL
      Q53SM2

    10. XM_047446494.1 → XP_047302450.1  histone deacetylase 4 isoform X25

      UniProtKB/TrEMBL
      Q53SM2

    11. XM_047446492.1 → XP_047302448.1  histone deacetylase 4 isoform X22

      UniProtKB/TrEMBL
      Q53SM2

    12. XM_047446482.1 → XP_047302438.1  histone deacetylase 4 isoform X14

      UniProtKB/TrEMBL
      Q53SM2

    13. XM_047446480.1 → XP_047302436.1  histone deacetylase 4 isoform X10

      UniProtKB/TrEMBL
      Q53SM2

    14. XM_047446479.1 → XP_047302435.1  histone deacetylase 4 isoform X9

      UniProtKB/Swiss-Prot
      E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
      UniProtKB/TrEMBL
      Q53SM2

    15. XM_011512223.3 → XP_011510525.1  histone deacetylase 4 isoform X6

      See identical proteins and their annotated locations for XP_011510525.1

      UniProtKB/TrEMBL
      A0A7I2SVS4, Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:91 → 152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:654 → 1062
      HDAC4; Histone deacetylase 4

    16. XM_011512222.4 → XP_011510524.1  histone deacetylase 4 isoform X6

      See identical proteins and their annotated locations for XP_011510524.1

      UniProtKB/TrEMBL
      A0A7I2SVS4, Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:91 → 152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:654 → 1062
      HDAC4; Histone deacetylase 4

    17. XM_047446484.1 → XP_047302440.1  histone deacetylase 4 isoform X14

      UniProtKB/TrEMBL
      Q53SM2

    18. XM_047446476.1 → XP_047302432.1  histone deacetylase 4 isoform X6

      UniProtKB/TrEMBL
      A0A7I2SVS4, Q53SM2

    19. XM_006712880.4 → XP_006712943.1  histone deacetylase 4 isoform X19

      See identical proteins and their annotated locations for XP_006712943.1

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:64 → 125
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:627 → 1035
      HDAC4; Histone deacetylase 4

    20. XM_047446487.1 → XP_047302443.1  histone deacetylase 4 isoform X18

      UniProtKB/TrEMBL
      Q53SM2

    21. XM_017005394.2 → XP_016860883.1  histone deacetylase 4 isoform X16

      UniProtKB/TrEMBL
      Q53SM2

    22. XM_011512219.3 → XP_011510521.1  histone deacetylase 4 isoform X4

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:115 → 176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:673 → 1076
      HDAC4; Histone deacetylase 4

    23. XM_006712877.4 → XP_006712940.1  histone deacetylase 4 isoform X2

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:115 → 176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:673 → 1081
      HDAC4; Histone deacetylase 4

    24. XM_011512218.3 → XP_011510520.1  histone deacetylase 4 isoform X3

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:115 → 176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:678 → 1081
      HDAC4; Histone deacetylase 4

    25. XM_011512217.3 → XP_011510519.1  histone deacetylase 4 isoform X1

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:115 → 176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:678 → 1086
      HDAC4; Histone deacetylase 4

    26. XM_047446481.1 → XP_047302437.1  histone deacetylase 4 isoform X12

      UniProtKB/TrEMBL
      Q53SM2

    27. XM_047446478.1 → XP_047302434.1  histone deacetylase 4 isoform X8

      UniProtKB/TrEMBL
      Q53SM2

    28. XM_047446477.1 → XP_047302433.1  histone deacetylase 4 isoform X7

      UniProtKB/TrEMBL
      Q53SM2

    29. XM_011512220.3 → XP_011510522.1  histone deacetylase 4 isoform X5

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:92 → 153
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:655 → 1063
      HDAC4; Histone deacetylase 4

    30. XM_047446497.1 → XP_047302453.1  histone deacetylase 4 isoform X28

      UniProtKB/TrEMBL
      Q53SM2

    31. XM_047446495.1 → XP_047302451.1  histone deacetylase 4 isoform X26

      UniProtKB/TrEMBL
      Q53SM2

    32. XM_011512225.3 → XP_011510527.1  histone deacetylase 4 isoform X13

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:86 → 147
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:644 → 1052
      HDAC4; Histone deacetylase 4

    33. XM_047446485.1 → XP_047302441.1  histone deacetylase 4 isoform X15

      UniProtKB/TrEMBL
      Q53SM2

    34. XM_011512224.3 → XP_011510526.1  histone deacetylase 4 isoform X11

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:86 → 147
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:649 → 1057
      HDAC4; Histone deacetylase 4

    35. XM_047446488.1 → XP_047302444.1  histone deacetylase 4 isoform X19

      UniProtKB/TrEMBL
      Q53SM2

    36. XM_024453257.2 → XP_024309025.1  histone deacetylase 4 isoform X19

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:64 → 125
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:627 → 1035
      HDAC4; Histone deacetylase 4

    37. XM_011512227.3 → XP_011510529.1  histone deacetylase 4 isoform X23

      UniProtKB/TrEMBL
      Q53SM2
      Conserved Domains (2) summary
      cd10162
      Location:43 → 104
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:606 → 1014
      HDAC4; Histone deacetylase 4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      239539541..239892233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344746.1 → XP_054200721.1  histone deacetylase 4 isoform X20

      UniProtKB/TrEMBL
      Q53SM2

    2. XM_054344742.1 → XP_054200717.1  histone deacetylase 4 isoform X17

      UniProtKB/TrEMBL
      Q53SM2

    3. XM_054344737.1 → XP_054200712.1  histone deacetylase 4 isoform X14

      UniProtKB/TrEMBL
      Q53SM2

    4. XM_054344756.1 → XP_054200731.1  histone deacetylase 4 isoform X29

      UniProtKB/TrEMBL
      Q53SM2

    5. XM_054344748.1 → XP_054200723.1  histone deacetylase 4 isoform X21

      UniProtKB/TrEMBL
      Q53SM2

    6. XM_054344747.1 → XP_054200722.1  histone deacetylase 4 isoform X20

      UniProtKB/TrEMBL
      Q53SM2

    7. XM_054344741.1 → XP_054200716.1  histone deacetylase 4 isoform X17

      UniProtKB/TrEMBL
      Q53SM2

    8. XM_054344754.1 → XP_054200729.1  histone deacetylase 4 isoform X27

      UniProtKB/TrEMBL
      Q53SM2

    9. XM_054344751.1 → XP_054200726.1  histone deacetylase 4 isoform X24

      UniProtKB/TrEMBL
      Q53SM2

    10. XM_054344752.1 → XP_054200727.1  histone deacetylase 4 isoform X25

      UniProtKB/TrEMBL
      Q53SM2

    11. XM_054344749.1 → XP_054200724.1  histone deacetylase 4 isoform X22

      UniProtKB/TrEMBL
      Q53SM2

    12. XM_054344736.1 → XP_054200711.1  histone deacetylase 4 isoform X14

      UniProtKB/TrEMBL
      Q53SM2

    13. XM_054344732.1 → XP_054200707.1  histone deacetylase 4 isoform X10

      UniProtKB/TrEMBL
      Q53SM2

    14. XM_054344728.1 → XP_054200703.1  histone deacetylase 4 isoform X6

      UniProtKB/TrEMBL
      A0A7I2SVS4, Q53SM2

    15. XM_054344731.1 → XP_054200706.1  histone deacetylase 4 isoform X9

      UniProtKB/Swiss-Prot
      E9PGB9, F5GX36, P56524, Q86YH7, Q9UND6
      UniProtKB/TrEMBL
      Q53SM2

    16. XM_054344727.1 → XP_054200702.1  histone deacetylase 4 isoform X6

      UniProtKB/TrEMBL
      A0A7I2SVS4, Q53SM2

    17. XM_054344738.1 → XP_054200713.1  histone deacetylase 4 isoform X14

      UniProtKB/TrEMBL
      Q53SM2

    18. XM_054344743.1 → XP_054200718.1  histone deacetylase 4 isoform X18

      UniProtKB/TrEMBL
      Q53SM2

    19. XM_054344740.1 → XP_054200715.1  histone deacetylase 4 isoform X16

      UniProtKB/TrEMBL
      Q53SM2

    20. XM_054344725.1 → XP_054200700.1  histone deacetylase 4 isoform X4

      UniProtKB/TrEMBL
      Q53SM2

    21. XM_054344724.1 → XP_054200699.1  histone deacetylase 4 isoform X3

      UniProtKB/TrEMBL
      Q53SM2

    22. XM_054344723.1 → XP_054200698.1  histone deacetylase 4 isoform X2

      UniProtKB/TrEMBL
      Q53SM2

    23. XM_054344722.1 → XP_054200697.1  histone deacetylase 4 isoform X1

      UniProtKB/TrEMBL
      Q53SM2

    24. XM_054344734.1 → XP_054200709.1  histone deacetylase 4 isoform X12

      UniProtKB/TrEMBL
      Q53SM2

    25. XM_054344729.1 → XP_054200704.1  histone deacetylase 4 isoform X7

      UniProtKB/TrEMBL
      Q53SM2

    26. XM_054344730.1 → XP_054200705.1  histone deacetylase 4 isoform X8

      UniProtKB/TrEMBL
      Q53SM2

    27. XM_054344726.1 → XP_054200701.1  histone deacetylase 4 isoform X5

      UniProtKB/TrEMBL
      Q53SM2

    28. XM_054344745.1 → XP_054200720.1  histone deacetylase 4 isoform X19

      UniProtKB/TrEMBL
      Q53SM2

    29. XM_054344755.1 → XP_054200730.1  histone deacetylase 4 isoform X28

      UniProtKB/TrEMBL
      Q53SM2

    30. XM_054344753.1 → XP_054200728.1  histone deacetylase 4 isoform X26

      UniProtKB/TrEMBL
      Q53SM2

    31. XM_054344735.1 → XP_054200710.1  histone deacetylase 4 isoform X13

      UniProtKB/TrEMBL
      Q53SM2

    32. XM_054344739.1 → XP_054200714.1  histone deacetylase 4 isoform X15

      UniProtKB/TrEMBL
      Q53SM2

    33. XM_054344733.1 → XP_054200708.1  histone deacetylase 4 isoform X11

      UniProtKB/TrEMBL
      Q53SM2

    34. XM_054344757.1 → XP_054200732.1  histone deacetylase 4 isoform X19

      UniProtKB/TrEMBL
      Q53SM2

    35. XM_054344744.1 → XP_054200719.1  histone deacetylase 4 isoform X19

      UniProtKB/TrEMBL
      Q53SM2

    36. XM_054344750.1 → XP_054200725.1  histone deacetylase 4 isoform X23

      UniProtKB/TrEMBL
      Q53SM2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56524.3 GenPept UniProtKB/Swiss-Prot:P56524

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