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    HOTTIP HOXA distal transcript antisense RNA [ Homo sapiens (human) ]

    Gene ID: 100316868, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HOTTIPprovided by HGNC
    Official Full Name
    HOXA distal transcript antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:37461
    See related
    MIM:614060; AllianceGenome:HGNC:37461
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOXA-AS6; HOXA13-AS1; NCRNA00213
    Summary
    This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in colon (RPKM 4.0), prostate (RPKM 3.7) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HOTTIP in Genome Data Viewer
    Location:
    7p15.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (27200421..27207259)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (27336410..27343254)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27240040..27246878)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27225097-27225978 Neighboring gene HOXA11 antisense RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27231749-27232306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27232307-27232864 Neighboring gene NUP98-HOXA13 recombination region Neighboring gene homeobox A13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27242057-27242581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244076-27244800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244801-27245523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27249966-27250466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27250467-27250967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27252523-27253272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27253273-27254021 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27259729-27260290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27264497-27265180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27282039-27282916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27284838-27285446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27285447-27286056 Neighboring gene EVX1 antisense RNA Neighboring gene VISTA enhancer hs629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27290949-27291652 Neighboring gene even-skipped homeobox 1 Neighboring gene ribosomal protein L35 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HOTTIP participates in mammary cancer by promoting cell proliferation via PI3K/AKT pathway. Gao W, et al. Eur Rev Med Pharmacol Sci, 2018 Jul. PMID 30024606
    2. Prognostic value of the long noncoding RNA HOTTIP in human cancers. Li W, et al. Oncotarget, 2017 Aug 29. PMID 28938659, Free PMC Article
    3. Long non‑coding RNA HOTTIP promotes hepatocellular carcinoma tumorigenesis and development: A comprehensive investigation based on bioinformatics, qRT‑PCR and meta‑analysis of 393 cases. Zhang Y, et al. Int J Oncol, 2017 Dec. PMID 29039502, Free PMC Article
    4. A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients. Sun Y, et al. Mol Cancer, 2017 Oct 17. PMID 29041935, Free PMC Article
    5. Long noncoding RNA HOTTIP promotes endothelial cell proliferation and migration via activation of the Wnt/β-catenin pathway. Liao B, et al. J Cell Biochem, 2018 Mar. PMID 29058802

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of Genetic Polymorphisms in Long Noncoding RNA HOTTIP with Risk of Idiopathic Recurrent Spontaneous Abortion.
      Title: Association of Genetic Polymorphisms in Long Noncoding RNA HOTTIP with Risk of Idiopathic Recurrent Spontaneous Abortion.
    2. Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway.
      Title: Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway.
    3. A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling.
      Title: A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling.
    4. Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma.
      Title: Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma.
    5. LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
      Title: LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
    6. A Computationally Constructed lncRNA-Associated Competing Triplet Network in Clear Cell Renal Cell Carcinoma.
      Title: A Computationally Constructed lncRNA-Associated Competing Triplet Network in Clear Cell Renal Cell Carcinoma.
    7. Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction.
      Title: Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction.
    8. LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2.
      Title: LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2.
    9. M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-kappaB pathway.
      Title: M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway.
    10. Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1alpha/VEGF signaling.
      Title: Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • HOXA cluster antisense RNA 6 (non-protein coding)
    • HOXA distal transcript antisense RNA (non-protein coding)
    • HOXA13 antisense RNA 1 (non-protein coding)
    • HoxA transcript at the distal tip

    Clone Names

    • FLJ36668

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables miRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables miRNA inhibitor activity via base-pairing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lncRNA-mediated post-transcriptional gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of miRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_037843.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004080

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      27200421..27207259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      27336410..27343254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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