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    Vcpkmt valosin containing protein lysine (K) methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 207965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vcpkmtprovided by MGI
    Official Full Name
    valosin containing protein lysine (K) methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2684917
    See related
    Ensembl:ENSMUSG00000049882 AllianceGenome:MGI:2684917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm71; VCP-KMT; Mettl21d; Mettl221d
    Summary
    Enables protein methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Orthologous to human VCPKMT (valosin containing protein lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.9), cerebellum adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vcpkmt in Genome Data Viewer
    Location:
    12 C2; 12 28.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69623504..69629883, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69576735..69583017, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70602988-70603097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70617614-70617767 Neighboring gene predicted gene, 46353 Neighboring gene STARR-positive B cell enhancer ABC_E7141 Neighboring gene STARR-seq mESC enhancer starr_32372 Neighboring gene predicted gene, 24449 Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene predicted gene, 31679

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice. Fusser M, et al. PLoS One, 2015. PMID 26544960, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
      Title: Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-lysine trimethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine trimethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein N-lysine methyltransferase METTL21D
    Names
    VCP lysine methyltransferase
    methyltransferase like 21D
    methyltransferase-like protein 21D
    protein-lysine methyltransferase METTL21D
    valosin-containing protein lysine methyltransferase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033236.3 → NP_001028408.2  protein N-lysine methyltransferase METTL21D isoform 2

      See identical proteins and their annotated locations for NP_001028408.2

      Status: VALIDATED

      Source sequence(s)
      AC153658
      Consensus CDS
      CCDS36464.1
      UniProtKB/Swiss-Prot
      B2RSP0, Q3UML0, Q8C436
      Related
      ENSMUSP00000055002.10, ENSMUST00000058639.11
      Conserved Domains (1) summary
      pfam10294
      Location:22 → 194
      Methyltransf_16; Lysine methyltransferase

    2. NM_001379044.1 → NP_001365973.1  protein N-lysine methyltransferase METTL21D isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153658
      Conserved Domains (1) summary
      pfam10294
      Location:22 → 194
      Methyltransf_16; Lysine methyltransferase

    RNA

    1. NR_166433.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658

    2. NR_166434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658

    3. NR_166435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658

    4. NR_166437.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153658

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69623504..69629883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157295.1 → XP_036013188.1  protein N-lysine methyltransferase METTL21D isoform X1

      Conserved Domains (1) summary
      pfam10294
      Location:54 → 226
      Methyltransf_16; Lysine methyltransferase

    RNA

    1. XR_004937479.1 RNA Sequence

      Related
      ENSMUST00000238220.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C436.2 GenPept UniProtKB/Swiss-Prot:Q8C436

    Gene LinkOut

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