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    Ephx4 epoxide hydrolase 4 [ Mus musculus (house mouse) ]

    Gene ID: 384214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ephx4provided by MGI
    Official Full Name
    epoxide hydrolase 4provided by MGI
    Primary source
    MGI:MGI:2686228
    See related
    Ensembl:ENSMUSG00000033805 AllianceGenome:MGI:2686228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abhd7; Ephxrp; Gm1382
    Summary
    Predicted to enable hydrolase activity. Predicted to be located in membrane. Orthologous to human EPHX4 (epoxide hydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 18.7), frontal lobe adult (RPKM 11.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ephx4 in Genome Data Viewer
    Location:
    5 E5- F; 5 52.23 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107551379..107577901)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107403513..107430035)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene bromodomain, testis-specific Neighboring gene predicted gene 17202 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene nuclear encoded rRNA 5S 173 Neighboring gene STARR-seq mESC enhancer starr_13889 Neighboring gene lysophosphatidylcholine acyltransferase 2B Neighboring gene BTB domain containing 8 Neighboring gene predicted gene, 33885

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation. Shen Y, et al. Cell Rep, 2024 Feb 27. PMID 38308845
    2. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Sirish P, et al. Proc Natl Acad Sci U S A, 2013 Apr 2. PMID 23493561, Free PMC Article
    3. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation.
      Title: ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epoxide hydrolase 4
    Names
    abhydrolase domain containing 7
    abhydrolase domain-containing protein 7
    epoxide hydrolase-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001804.2 → NP_001001804.2  epoxide hydrolase 4 isoform 1

      See identical proteins and their annotated locations for NP_001001804.2

      Status: VALIDATED

      Source sequence(s)
      AC126598, BN000367
      Consensus CDS
      CCDS19501.1
      UniProtKB/Swiss-Prot
      F8VQ47, Q6IE26
      Related
      ENSMUSP00000043764.6, ENSMUST00000049146.12
      Conserved Domains (1) summary
      COG0596
      Location:74 → 353
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    2. NM_001379224.1 → NP_001366153.1  epoxide hydrolase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126598
      Conserved Domains (1) summary
      COG0596
      Location:1 → 260
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    3. NM_001379225.1 → NP_001366154.1  epoxide hydrolase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126598
      Conserved Domains (1) summary
      COG0596
      Location:1 → 260
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107551379..107577901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IE26.2 GenPept UniProtKB/Swiss-Prot:Q6IE26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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