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    Ptpru protein tyrosine phosphatase receptor type U [ Mus musculus (house mouse) ]

    Gene ID: 19273, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptpruprovided by MGI
    Official Full Name
    protein tyrosine phosphatase receptor type Uprovided by MGI
    Primary source
    MGI:MGI:1321151
    See related
    Ensembl:ENSMUSG00000028909 AllianceGenome:MGI:1321151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTP; Pcp2; Ptpf; Ftp-1; PCP-2; Ptprl; R-PTP-U; PTPlambda; R-PTP-psi; PTP-lambda; RPTPlambda
    Summary
    Enables beta-catenin binding activity. Acts upstream of or within homotypic cell-cell adhesion. Predicted to be located in cell-cell junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PTPRU (protein tyrosine phosphatase receptor type U). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 20.7), bladder adult (RPKM 17.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptpru in Genome Data Viewer
    Location:
    4 D2.3; 4 64.5 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131495768..131565617, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131768457..131838306, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568696 Neighboring gene STARR-seq mESC enhancer starr_11548 Neighboring gene predicted gene, 42321 Neighboring gene predicted gene, 52680 Neighboring gene STARR-positive B cell enhancer ABC_E10262 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine-rich splicing factor 4 Neighboring gene predicted gene 12992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and alternative splicing of murine R2B receptor protein tyrosine phosphatases (PTPkappa, mu, rho and PCP-2). Besco J, et al. BMC Genomics, 2004 Feb 11. PMID 15040814, Free PMC Article
    2. Molecular cloning of a novel receptor-type protein tyrosine phosphatase from murine fetal liver. Yoneya T, et al. Gene, 1997 Jul 31. PMID 9272866
    3. A novel protein-tyrosine phosphatase related to the homotypically adhering kappa and mu receptors. Cheng J, et al. J Biol Chem, 1997 Mar 14. PMID 9054423
    4. Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development. Fuchs M, et al. Mech Dev, 1998 Jan. PMID 9510027
    5. Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. Avraham S, et al. Gene, 1997 Dec 19. PMID 9434160

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase U
    Names
    Pancreatic carcinoma phosphatase 2
    Protein-tyrosine phosphatase-lamda
    Receptor-type protein-tyrosine phosphatase psi
    protein tyrosine phosphatase, receptor type, L
    NP_001076588.1
    NP_035344.2
    XP_006538729.1
    XP_006538730.1
    XP_006538731.1
    XP_006538733.1
    XP_006538735.1
    XP_006538736.1
    XP_006538737.1
    XP_011248512.1
    XP_011248513.1
    XP_011248514.1
    XP_011248515.1
    XP_011248516.1
    XP_011248517.1
    XP_036019791.1
    XP_036019793.1
    XP_036019794.1
    XP_036019795.1
    XP_036019796.1
    XP_036019797.1
    XP_036019798.1
    XP_036019799.1
    XP_036019800.1
    XP_036019801.1
    XP_036019802.1
    XP_036019803.1
    XP_036019804.1
    XP_036019805.1
    XP_036019806.1
    XP_036019807.1
    XP_036019808.1
    XP_036019809.1
    XP_036019810.1
    XP_036019811.1
    XP_036019812.1
    XP_036019813.1
    XP_036019814.1
    XP_036019815.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083119.3 → NP_001076588.1  receptor-type tyrosine-protein phosphatase U isoform 2 precursor

      See identical proteins and their annotated locations for NP_001076588.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AL670959
      Consensus CDS
      CCDS38896.1
      UniProtKB/Swiss-Prot
      B1AUH1, O35564, P70125, Q3V312, Q66JV9
      Related
      ENSMUSP00000030741.3, ENSMUST00000030741.9
      Conserved Domains (8) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1175 → 1438
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:922 → 1143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1143
      Y_phosphatase; Protein-tyrosine phosphatase

    2. NM_011214.3 → NP_035344.2  receptor-type tyrosine-protein phosphatase U isoform 1 precursor

      See identical proteins and their annotated locations for NP_035344.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 1, which is shorter than isoform 2.
      Source sequence(s)
      AL670959
      Consensus CDS
      CCDS18714.1
      UniProtKB/Swiss-Prot
      B1AUH1
      UniProtKB/TrEMBL
      Q80ZN2
      Related
      ENSMUSP00000101607.3, ENSMUST00000105987.9
      Conserved Domains (8) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1165 → 1428
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:912 → 1133
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1133
      Y_phosphatase; Protein-tyrosine phosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131495768..131565617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250210.4 → XP_011248512.1  receptor-type tyrosine-protein phosphatase U isoform X1

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:204 → 290
      IG; Immunoglobulin
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1259 → 1465
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain
      cl28904
      Location:951 → 1174
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_036163920.1 → XP_036019813.1  receptor-type tyrosine-protein phosphatase U isoform X30

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:608 → 812
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:897 → 1103
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain

    3. XM_036163915.1 → XP_036019808.1  receptor-type tyrosine-protein phosphatase U isoform X27

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:916 → 1122
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain
      cl28904
      Location:608 → 831
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_036163909.1 → XP_036019802.1  receptor-type tyrosine-protein phosphatase U isoform X24

      Conserved Domains (6) summary
      smart00410
      Location:44 → 130
      IG_like; Immunoglobulin like
      cd00063
      Location:234 → 329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:781 → 985
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:1070 → 1276
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:342 → 425
      fn3; Fibronectin type III domain
      cl27660
      Location:7 → 34
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

    5. XM_036163918.1 → XP_036019811.1  receptor-type tyrosine-protein phosphatase U isoform X30

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:608 → 812
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:897 → 1103
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain

    6. XM_036163914.1 → XP_036019807.1  receptor-type tyrosine-protein phosphatase U isoform X27

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:916 → 1122
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain
      cl28904
      Location:608 → 831
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_036163917.1 → XP_036019810.1  receptor-type tyrosine-protein phosphatase U isoform X29

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:904 → 1110
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain
      cl28904
      Location:618 → 819
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    8. XM_036163912.1 → XP_036019805.1  receptor-type tyrosine-protein phosphatase U isoform X26

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:926 → 1132
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain
      cl28904
      Location:618 → 841
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    9. XM_036163901.1 → XP_036019794.1  receptor-type tyrosine-protein phosphatase U isoform X13

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:196 → 282
      IG; Immunoglobulin
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1232 → 1438
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cl28904
      Location:933 → 1147
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    10. XM_036163900.1 → XP_036019793.1  receptor-type tyrosine-protein phosphatase U isoform X12

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:196 → 282
      IG; Immunoglobulin
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1235 → 1441
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cl28904
      Location:933 → 1150
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    11. XM_006538673.4 → XP_006538736.1  receptor-type tyrosine-protein phosphatase U isoform X16

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1228 → 1434
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:291 → 365
      fn3; Fibronectin type III domain
      cl28904
      Location:933 → 1143
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    12. XM_011250215.4 → XP_011248517.1  receptor-type tyrosine-protein phosphatase U isoform X9

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:196 → 282
      IG; Immunoglobulin
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1241 → 1447
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:291 → 365
      fn3; Fibronectin type III domain
      cl28904
      Location:933 → 1156
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    13. XM_036163902.1 → XP_036019795.1  receptor-type tyrosine-protein phosphatase U isoform X15

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:196 → 282
      IG; Immunoglobulin
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1229 → 1435
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cl28904
      Location:943 → 1144
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    14. XM_011250213.4 → XP_011248515.1  receptor-type tyrosine-protein phosphatase U isoform X4

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1251 → 1457
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:291 → 365
      fn3; Fibronectin type III domain
      cl28904
      Location:943 → 1166
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    15. XM_006538674.4 → XP_006538737.1  receptor-type tyrosine-protein phosphatase U isoform X18

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:196 → 282
      IG; Immunoglobulin
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1219 → 1425
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:291 → 365
      fn3; Fibronectin type III domain
      cl28904
      Location:933 → 1134
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    16. XM_036163898.1 → XP_036019791.1  receptor-type tyrosine-protein phosphatase U isoform X7

      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:196 → 282
      IG; Immunoglobulin
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1245 → 1451
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cl28904
      Location:943 → 1160
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    17. XM_036163911.1 → XP_036019804.1  receptor-type tyrosine-protein phosphatase U isoform X25

      Conserved Domains (6) summary
      smart00410
      Location:44 → 130
      IG_like; Immunoglobulin like
      cd00063
      Location:234 → 329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1067 → 1273
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:342 → 425
      fn3; Fibronectin type III domain
      cl27660
      Location:7 → 34
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cl28904
      Location:781 → 982
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    18. XM_036163908.1 → XP_036019801.1  receptor-type tyrosine-protein phosphatase U isoform X23

      Conserved Domains (6) summary
      smart00409
      Location:44 → 130
      IG; Immunoglobulin
      cd00063
      Location:234 → 329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1077 → 1283
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:342 → 425
      fn3; Fibronectin type III domain
      cl27660
      Location:7 → 34
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cl28904
      Location:791 → 992
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    19. XM_036163907.1 → XP_036019800.1  receptor-type tyrosine-protein phosphatase U isoform X22

      Conserved Domains (6) summary
      smart00410
      Location:44 → 130
      IG_like; Immunoglobulin like
      cd00063
      Location:234 → 329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:791 → 995
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:1080 → 1286
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:342 → 425
      fn3; Fibronectin type III domain
      cl27660
      Location:7 → 34
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

    20. XM_036163921.1 → XP_036019814.1  receptor-type tyrosine-protein phosphatase U isoform X31

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:894 → 1100
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain
      cl28904
      Location:608 → 809
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    21. XM_036163916.1 → XP_036019809.1  receptor-type tyrosine-protein phosphatase U isoform X28

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:618 → 822
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:907 → 1113
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain

    22. XM_036163905.1 → XP_036019798.1  receptor-type tyrosine-protein phosphatase U isoform X20

      Conserved Domains (6) summary
      smart00137
      Location:1 → 114
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:124 → 210
      IG; Immunoglobulin
      cd00063
      Location:314 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:861 → 1065
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:1150 → 1356
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:422 → 505
      fn3; Fibronectin type III domain

    23. XM_036163904.1 → XP_036019797.1  receptor-type tyrosine-protein phosphatase U isoform X19

      Conserved Domains (6) summary
      smart00137
      Location:1 → 114
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:124 → 210
      IG_like; Immunoglobulin like
      cd00063
      Location:314 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:871 → 1075
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:1160 → 1366
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:422 → 505
      fn3; Fibronectin type III domain

    24. XM_036163906.1 → XP_036019799.1  receptor-type tyrosine-protein phosphatase U isoform X21

      Conserved Domains (6) summary
      smart00137
      Location:1 → 114
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:124 → 210
      IG_like; Immunoglobulin like
      cd00063
      Location:314 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1147 → 1353
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:422 → 505
      fn3; Fibronectin type III domain
      cl28904
      Location:861 → 1062
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    25. XM_036163910.1 → XP_036019803.1  receptor-type tyrosine-protein phosphatase U isoform X24

      Conserved Domains (6) summary
      smart00410
      Location:44 → 130
      IG_like; Immunoglobulin like
      cd00063
      Location:234 → 329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:781 → 985
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:1070 → 1276
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:342 → 425
      fn3; Fibronectin type III domain
      cl27660
      Location:7 → 34
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

    26. XM_036163919.1 → XP_036019812.1  receptor-type tyrosine-protein phosphatase U isoform X30

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:608 → 812
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:897 → 1103
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain

    27. XM_036163913.1 → XP_036019806.1  receptor-type tyrosine-protein phosphatase U isoform X26

      Conserved Domains (4) summary
      cd00063
      Location:61 → 156
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:926 → 1132
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:169 → 252
      fn3; Fibronectin type III domain
      cl28904
      Location:618 → 841
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    28. XM_011250211.4 → XP_011248513.1  receptor-type tyrosine-protein phosphatase U isoform X2

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:204 → 290
      IG; Immunoglobulin
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1256 → 1462
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain
      cl28904
      Location:951 → 1171
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    29. XM_006538667.5 → XP_006538730.1  receptor-type tyrosine-protein phosphatase U isoform X8

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:204 → 290
      IG_like; Immunoglobulin like
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1243 → 1449
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain
      cl28904
      Location:951 → 1158
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    30. XM_011250214.4 → XP_011248516.1  receptor-type tyrosine-protein phosphatase U isoform X5

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:204 → 290
      IG_like; Immunoglobulin like
      cd00063
      Location:492 → 593
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1249 → 1455
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:299 → 373
      fn3; Fibronectin type III domain
      cl28904
      Location:941 → 1164
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    31. XM_011250212.4 → XP_011248514.1  receptor-type tyrosine-protein phosphatase U isoform X3

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:204 → 290
      IG; Immunoglobulin
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1253 → 1459
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain
      cl28904
      Location:951 → 1168
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    32. XM_006538670.5 → XP_006538733.1  receptor-type tyrosine-protein phosphatase U isoform X11

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:204 → 290
      IG; Immunoglobulin
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1237 → 1443
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain
      cl28904
      Location:951 → 1152
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    33. XM_006538666.5 → XP_006538729.1  receptor-type tyrosine-protein phosphatase U isoform X6

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:204 → 290
      IG_like; Immunoglobulin like
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1246 → 1452
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain
      cl28904
      Location:951 → 1161
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    34. XM_036163903.1 → XP_036019796.1  receptor-type tyrosine-protein phosphatase U isoform X17

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:204 → 290
      IG; Immunoglobulin
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14637
      Location:1227 → 1433
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain
      cl28904
      Location:941 → 1142
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    35. XM_006538668.5 → XP_006538731.1  receptor-type tyrosine-protein phosphatase U isoform X10

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:204 → 290
      IG; Immunoglobulin
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:951 → 1155
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:1240 → 1446
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain

    36. XM_006538672.5 → XP_006538735.1  receptor-type tyrosine-protein phosphatase U isoform X14

      Conserved Domains (6) summary
      smart00137
      Location:31 → 194
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00409
      Location:204 → 290
      IG; Immunoglobulin
      cd00063
      Location:394 → 489
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14632
      Location:941 → 1145
      R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
      cd14637
      Location:1230 → 1436
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:502 → 585
      fn3; Fibronectin type III domain

    37. XM_036163922.1 → XP_036019815.1  receptor-type tyrosine-protein phosphatase U isoform X32

      Conserved Domains (3) summary
      cd14637
      Location:811 → 1017
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      pfam00041
      Location:54 → 137
      fn3; Fibronectin type III domain
      cl28904
      Location:503 → 726
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AUH1.1 GenPept UniProtKB/Swiss-Prot:B1AUH1

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