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    Agmo alkylglycerol monooxygenase [ Mus musculus (house mouse) ]

    Gene ID: 319660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agmoprovided by MGI
    Official Full Name
    alkylglycerol monooxygenaseprovided by MGI
    Primary source
    MGI:MGI:2442495
    See related
    Ensembl:ENSMUSG00000050103 AllianceGenome:MGI:2442495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem195; A530016O06Rik
    Summary
    Enables glyceryl-ether monooxygenase activity. Involved in triglyceride biosynthetic process. Is active in endoplasmic reticulum membrane. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 14.5), large intestine adult (RPKM 8.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Agmo in Genome Data Viewer
    Location:
    12 A3; 12 16.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (37291638..37632201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (37241639..37581932)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31928 Neighboring gene predicted gene 29007 Neighboring gene mesenchyme homeobox 2 Neighboring gene predicted gene, 34408 Neighboring gene STARR-seq mESC enhancer starr_31930 Neighboring gene STARR-seq mESC enhancer starr_31931 Neighboring gene STARR-seq mESC enhancer starr_31932 Neighboring gene STARR-seq mESC enhancer starr_31933 Neighboring gene STARR-seq mESC enhancer starr_31934 Neighboring gene diacylglycerol kinase, beta Neighboring gene STARR-seq mESC enhancer starr_31935 Neighboring gene predicted gene, 35755 Neighboring gene predicted gene, 52011

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown. Sailer S, et al. J Lipid Res, 2022 Jun. PMID 35537527, Free PMC Article
    2. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Schmitz K, et al. Neurotherapeutics, 2021 Jul. PMID 33844153, Free PMC Article
    3. Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Watschinger K, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675482, Free PMC Article
    4. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. Tokuoka SM, et al. Biochem Biophys Res Commun, 2013 Jun 28. PMID 23743196
    5. Alterations in ether lipid metabolism and the consequences for the mouse lipidome. Lackner K, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 Apr. PMID 36690320

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glyceryl-ether monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyceryl-ether monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glyceryl-ether monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glyceryl-ether monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glyceryl-ether monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ether lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alkylglycerol monooxygenase
    Names
    transmembrane protein 195
    NP_848882.2
    XP_011242177.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178767.5 → NP_848882.2  alkylglycerol monooxygenase

      See identical proteins and their annotated locations for NP_848882.2

      Status: PROVISIONAL

      Source sequence(s)
      AK040702
      Consensus CDS
      CCDS49052.1
      UniProtKB/Swiss-Prot
      Q3TR15, Q8BS35, Q8C7H5, Q8CAA6
      Related
      ENSMUSP00000051441.8, ENSMUST00000049874.14
      Conserved Domains (2) summary
      COG3000
      Location:43 → 256
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:121 → 249
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      37291638..37632201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243875.3 → XP_011242177.1  alkylglycerol monooxygenase isoform X1

      Related
      ENSMUSP00000123801.2, ENSMUST00000159998.8
      Conserved Domains (1) summary
      COG3000
      Location:43 → 256
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

    RNA

    1. XR_004937507.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BS35.1 GenPept UniProtKB/Swiss-Prot:Q8BS35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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