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    Cenpn centromere protein N [ Mus musculus (house mouse) ]

    Gene ID: 72155, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cenpnprovided by MGI
    Official Full Name
    centromere protein Nprovided by MGI
    Primary source
    MGI:MGI:1919405
    See related
    Ensembl:ENSMUSG00000031756 AllianceGenome:MGI:1919405
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610510J17Rik
    Summary
    Predicted to be involved in CENP-A containing chromatin assembly. Predicted to be part of inner kinetochore. Predicted to be active in nucleoplasm. Is expressed in cerebral cortex ventricular layer. Orthologous to human CENPN (centromere protein N). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 55.4), CNS E11.5 (RPKM 13.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpn in Genome Data Viewer
    Location:
    8 E1; 8 63.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117648448..117668243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (116921716..116941504)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene predicted gene, 42045 Neighboring gene C-X9-C motif containing 2 Neighboring gene STARR-seq mESC enhancer starr_22803 Neighboring gene STARR-positive B cell enhancer ABC_E6690 Neighboring gene ATM interactor Neighboring gene RIKEN cDNA 1700030J22 gene Neighboring gene STARR-positive B cell enhancer ABC_E2878

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein N
    Names
    CENP-N

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028131.3 → NP_082407.1  centromere protein N

      See identical proteins and their annotated locations for NP_082407.1

      Status: PROVISIONAL

      Source sequence(s)
      AC121101, AC162858
      Consensus CDS
      CCDS22693.1
      UniProtKB/Swiss-Prot
      Q6PE73, Q8R2W7, Q9CZW2
      Related
      ENSMUSP00000034205.5, ENSMUST00000034205.5
      Conserved Domains (1) summary
      pfam05238
      Location:3 → 337
      CENP-N; Kinetochore protein CHL4 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      117648448..117668243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154305.1 → XP_036010198.1  centromere protein N isoform X2

      Conserved Domains (1) summary
      pfam05238
      Location:4 → 211
      CENP-N; Kinetochore protein CHL4 like

    2. XM_006531387.4 → XP_006531450.1  centromere protein N isoform X1

      See identical proteins and their annotated locations for XP_006531450.1

      UniProtKB/Swiss-Prot
      Q6PE73, Q8R2W7, Q9CZW2
      Conserved Domains (1) summary
      pfam05238
      Location:3 → 337
      CENP-N; Kinetochore protein CHL4 like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZW2.1 GenPept UniProtKB/Swiss-Prot:Q9CZW2

    Gene LinkOut

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